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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi394 – 401ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:SO_2802
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

Q8EDF0:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalUniRule annotationAdd BLAST21
Transmembranei81 – 101HelicalUniRule annotationAdd BLAST21
Transmembranei160 – 180HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei267 – 287HelicalUniRule annotationAdd BLAST21
Transmembranei296 – 316HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925991 – 601Lipid A export ATP-binding/permease protein MsbAAdd BLAST601

Proteomic databases

PaxDbiQ8EDF0.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi211586.SO_2802.

Structurei

3D structure databases

ProteinModelPortaliQ8EDF0.
SMRiQ8EDF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 328ABC transmembrane type-1UniRule annotationAdd BLAST302
Domaini360 – 597ABC transporterUniRule annotationAdd BLAST238

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.
PhylomeDBiQ8EDF0.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EDF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASPKNEMW TVFKRLMGYL KPMKGMFLLS VVGLIVYGLV DAAFISFIGP
60 70 80 90 100
FIDKGFSSSA PAISNGIALP TSQGFHADNQ VLLMAPIVVI LMFSLRGFAN
110 120 130 140 150
FVSTYGISYM SARLIMDMRQ QVFEHYLSLP VSYMDKENTG NLISKVTFDT
160 170 180 190 200
EQIARASGSA LISIVRDSVT IIGMLGLMFY NSWKLSLCIL VIGPIMGVVI
210 220 230 240 250
TIVSRRFRKV SKQIQTAMGD VSAATEQMIK GHKNVLAFGG QETETARFAK
260 270 280 290 300
INDRNRHQNM KLAVAQAVSQ PLIMVIGSFA LAFVLYAASL DSMKADLTAG
310 320 330 340 350
TFATILGAMM AMLQPIKNLT RVNAEFQRGI AACTTVFELL DTVPESDTGT
360 370 380 390 400
YTVARAKGNL RFDNVSFSYE GQERRALEKI DFEVSQGQTL ALVGRSGSGK
410 420 430 440 450
STIASLVTRF YTGLESGDIL LDDVSIYDYS LKSLRSQVAL VSQQVTLFND
460 470 480 490 500
TIANNIAYAY PGEVTREQII EAATLAHAME FIEQLPDGLD TQVGENGVLL
510 520 530 540 550
SGGQRQRIAI ARAMLRDAPV LILDEATSAL DTESEKAIQQ GLDNLRQNRT
560 570 580 590 600
SVVIAHRLST IESADQILVV DQGRIVERGT HKSLLELGGM YAKLYQMQFG

S
Length:601
Mass (Da):65,712
Last modified:March 1, 2003 - v1
Checksum:i054C0A99C5B9B5E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN55824.1.
RefSeqiNP_718380.1. NC_004347.2.
WP_011072735.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN55824; AAN55824; SO_2802.
GeneIDi1170502.
KEGGison:SO_2802.
PATRICifig|211586.12.peg.2703.

Similar proteinsi

Entry informationi

Entry nameiMSBA_SHEON
AccessioniPrimary (citable) accession number: Q8EDF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families