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Protein

Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon

Gene

cheB1

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193UniRule annotation1
Active sitei220UniRule annotation1
Active sitei316UniRule annotation1

GO - Molecular functioni

  • phosphorelay response regulator activity Source: InterPro
  • protein-glutamate methylesterase activity Source: TIGR

GO - Biological processi

  • chemotaxis Source: TIGR

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase of group 1 operonUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB1UniRule annotation
Synonyms:cheB3
Ordered Locus Names:SO_3206
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580281 – 374Chemotaxis response regulator protein-glutamate methylesterase of group 1 operonAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8ECD7.

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_3206.

Structurei

3D structure databases

ProteinModelPortaliQ8ECD7.
SMRiQ8ECD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini174 – 374CheB-type methylesteraseUniRule annotationAdd BLAST201

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiYGMPMAV.
OrthoDBiPOG091H045J.
PhylomeDBiQ8ECD7.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ECD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKVLVVDD SSFFRRRVSE IVNQDPELEV IATASNGAEA VKMTADLNPQ
60 70 80 90 100
VITMDIEMPV MDGITAVREI MAKCPTPILM FSSLTHDGAK ATLDALDAGA
110 120 130 140 150
LDFLPKRFED IATNKDEAIL LLQQRVKALG RRRIFRPITR PSVAPVTPRP
160 170 180 190 200
TTGSAVGNAT TPVQSASAPV RSSPLSSIRA SGKQYKLLLI GTSTGGPVAL
210 220 230 240 250
QKVLTQFPAN YPHPILLIQH MPAAFTPAFA SRLNGLCKIE VKEAANGDIL
260 270 280 290 300
RPGCAYLAPG GMQMMVERAG VTGRIKVLAG SAEMNYKPCV DITFASASKA
310 320 330 340 350
YGGDVLAVVL TGMGADGREG ARMLKAAGAT IWAQDEASCV VYGMPQAVAS
360 370
TGIATQSISL DNMAESILKE SARG
Length:374
Mass (Da):39,484
Last modified:March 1, 2003 - v1
Checksum:i8F58AC58392B3D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN56205.1.
RefSeqiNP_718761.1. NC_004347.2.
WP_011073092.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN56205; AAN56205; SO_3206.
GeneIDi1170899.
KEGGison:SO_3206.
PATRICifig|211586.12.peg.3112.

Similar proteinsi

Entry informationi

Entry nameiCHEB1_SHEON
AccessioniPrimary (citable) accession number: Q8ECD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome