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Q8EBX8

- TRMB_SHEON

UniProt

Q8EBX8 - TRMB_SHEON

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681S-adenosyl-L-methionineUniRule annotation
Binding sitei93 – 931S-adenosyl-L-methionineUniRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionineUniRule annotation
Active sitei143 – 1431By similarity
Binding sitei143 – 1431S-adenosyl-L-methionineUniRule annotation
Binding sitei147 – 1471SubstrateUniRule annotation
Binding sitei179 – 1791SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:SO_3367
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238tRNA (guanine-N(7)-)-methyltransferasePRO_0000171386Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_3367.

Structurei

3D structure databases

ProteinModelPortaliQ8EBX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni216 – 2194Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiTSATNDY.
OrthoDBiEOG6K6VBC.
PhylomeDBiQ8EBX8.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EBX8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEVTTAEFN EEGKYLRKIR SFVLREGRLT KGQAQAIETQ WPTMGLDYSP
60 70 80 90 100
APLDLADVFG RKADTVLEIG FGMGASLVQM AQEAPELNFI GIEVHKPGVG
110 120 130 140 150
SCLSDAAAAG VTNLRVYHHD AMEVLEHAIA DGSLTRVQLF FPDPWHKKRH
160 170 180 190 200
HKRRIVQAEF AELIRRKLKI GGVFHMATDW ENYSEHMLEV MNVASGYKNQ
210 220 230
SADGTVVPRP DHRPLTKFEA RGHRLGHGVW DLMFERIA
Length:238
Mass (Da):26,774
Last modified:March 1, 2003 - v1
Checksum:i33B114D23B132B1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN56365.1.
RefSeqiNP_718921.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN56365; AAN56365; SO_3367.
GeneIDi1171047.
KEGGison:SO_3367.
PATRICi23526408. VBISheOne101494_3267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN56365.1 .
RefSeqi NP_718921.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EBX8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_3367.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN56365 ; AAN56365 ; SO_3367 .
GeneIDi 1171047.
KEGGi son:SO_3367.
PATRICi 23526408. VBISheOne101494_3267.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi TSATNDY.
OrthoDBi EOG6K6VBC.
PhylomeDBi Q8EBX8.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiTRMB_SHEON
AccessioniPrimary (citable) accession number: Q8EBX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3