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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-3402-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:SO_3654
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761351 – 218Uracil-DNA glycosylaseAdd BLAST218

Proteomic databases

PaxDbiQ8EB78
PRIDEiQ8EB78

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_3654

Structurei

3D structure databases

ProteinModelPortaliQ8EB78
SMRiQ8EB78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL
PhylomeDBiQ8EB78

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EB78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWPAFIDHQ RTQPYYQQLI AFVNQERQVG KVIYPPKEDV FNAFKTTPLE
60 70 80 90 100
QVRVVLIGQD PYHGPDQAHG LCFSVKRGVK APPSLANMYK ELVNDIPGFH
110 120 130 140 150
IPNHGDLTQW AEQGILMLNT VLTVEQGQAH SHANAGWEIF TTEALKLLNA
160 170 180 190 200
QERPIIFVLW GSHAIKKGAV ITAPQHQILS GPHPSPLSAY RGFFGCGHFS
210
KVNQLLMARG EAPIQWQI
Length:218
Mass (Da):24,434
Last modified:March 1, 2003 - v1
Checksum:i751FF4DC183851B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN56640.1
RefSeqiNP_719196.1, NC_004347.2
WP_011073453.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN56640; AAN56640; SO_3654
GeneIDi1171313
KEGGison:SO_3654
PATRICifig|211586.12.peg.3542

Similar proteinsi

Entry informationi

Entry nameiUNG_SHEON
AccessioniPrimary (citable) accession number: Q8EB78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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