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Q8EB78 (UNG_SHEON) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uracil-DNA glycosylase

Short name=UDG
EC=3.2.2.27
Gene names
Name:ung
Ordered Locus Names:SO_3654
OrganismShewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP]
Taxonomic identifier211586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity. HAMAP-Rule MF_00148

Catalytic activity

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. HAMAP-Rule MF_00148

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00148.

Sequence similarities

Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbase-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuracil DNA N-glycosylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Uracil-DNA glycosylase HAMAP-Rule MF_00148
PRO_0000176135

Sites

Active site601Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EB78 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 751FF4DC183851B3

FASTA21824,434
        10         20         30         40         50         60 
MTWPAFIDHQ RTQPYYQQLI AFVNQERQVG KVIYPPKEDV FNAFKTTPLE QVRVVLIGQD 

        70         80         90        100        110        120 
PYHGPDQAHG LCFSVKRGVK APPSLANMYK ELVNDIPGFH IPNHGDLTQW AEQGILMLNT 

       130        140        150        160        170        180 
VLTVEQGQAH SHANAGWEIF TTEALKLLNA QERPIIFVLW GSHAIKKGAV ITAPQHQILS 

       190        200        210 
GPHPSPLSAY RGFFGCGHFS KVNQLLMARG EAPIQWQI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014299 Genomic DNA. Translation: AAN56640.1.
RefSeqNP_719196.1. NC_004347.2.

3D structure databases

ProteinModelPortalQ8EB78.
SMRQ8EB78. Positions 1-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING211586.SO_3654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN56640; AAN56640; SO_3654.
GeneID1171313.
KEGGson:SO_3654.
PATRIC23526994. VBISheOne101494_3542.

Phylogenomic databases

eggNOGCOG0692.
HOGENOMHOG000229528.
KOK03648.
OMAAGKEIYP.
OrthoDBEOG6MSS63.
ProtClustDBPRK05254.

Family and domain databases

Gene3D3.40.470.10. 1 hit.
HAMAPMF_00148. UDG.
InterProIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERPTHR11264. PTHR11264. 1 hit.
PfamPF03167. UDG. 1 hit.
[Graphical view]
SMARTSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMSSF52141. SSF52141. 1 hit.
TIGRFAMsTIGR00628. ung. 1 hit.
PROSITEPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUNG_SHEON
AccessionPrimary (citable) accession number: Q8EB78
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families