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Q8EB78

- UNG_SHEON

UniProt

Q8EB78 - UNG_SHEON

Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

    Catalytic activityi

    Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei60 – 601Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
    Short name:
    UDGUniRule annotation
    Gene namesi
    Name:ungUniRule annotation
    Ordered Locus Names:SO_3654
    OrganismiShewanella oneidensis (strain MR-1)
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Uracil-DNA glycosylasePRO_0000176135Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_3654.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EB78.
    SMRiQ8EB78. Positions 1-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the uracil-DNA glycosylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0692.
    HOGENOMiHOG000229528.
    KOiK03648.
    OMAiQNIFKEM.
    OrthoDBiEOG6MSS63.
    PhylomeDBiQ8EB78.

    Family and domain databases

    Gene3Di3.40.470.10. 1 hit.
    HAMAPiMF_00148. UDG.
    InterProiIPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view]
    PANTHERiPTHR11264. PTHR11264. 1 hit.
    PfamiPF03167. UDG. 1 hit.
    [Graphical view]
    SMARTiSM00986. UDG. 1 hit.
    [Graphical view]
    SUPFAMiSSF52141. SSF52141. 1 hit.
    TIGRFAMsiTIGR00628. ung. 1 hit.
    PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EB78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTWPAFIDHQ RTQPYYQQLI AFVNQERQVG KVIYPPKEDV FNAFKTTPLE    50
    QVRVVLIGQD PYHGPDQAHG LCFSVKRGVK APPSLANMYK ELVNDIPGFH 100
    IPNHGDLTQW AEQGILMLNT VLTVEQGQAH SHANAGWEIF TTEALKLLNA 150
    QERPIIFVLW GSHAIKKGAV ITAPQHQILS GPHPSPLSAY RGFFGCGHFS 200
    KVNQLLMARG EAPIQWQI 218
    Length:218
    Mass (Da):24,434
    Last modified:March 1, 2003 - v1
    Checksum:i751FF4DC183851B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN56640.1.
    RefSeqiNP_719196.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN56640; AAN56640; SO_3654.
    GeneIDi1171313.
    KEGGison:SO_3654.
    PATRICi23526994. VBISheOne101494_3542.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN56640.1 .
    RefSeqi NP_719196.1. NC_004347.2.

    3D structure databases

    ProteinModelPortali Q8EB78.
    SMRi Q8EB78. Positions 1-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_3654.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN56640 ; AAN56640 ; SO_3654 .
    GeneIDi 1171313.
    KEGGi son:SO_3654.
    PATRICi 23526994. VBISheOne101494_3542.

    Phylogenomic databases

    eggNOGi COG0692.
    HOGENOMi HOG000229528.
    KOi K03648.
    OMAi QNIFKEM.
    OrthoDBi EOG6MSS63.
    PhylomeDBi Q8EB78.

    Family and domain databases

    Gene3Di 3.40.470.10. 1 hit.
    HAMAPi MF_00148. UDG.
    InterProi IPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view ]
    PANTHERi PTHR11264. PTHR11264. 1 hit.
    Pfami PF03167. UDG. 1 hit.
    [Graphical view ]
    SMARTi SM00986. UDG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52141. SSF52141. 1 hit.
    TIGRFAMsi TIGR00628. ung. 1 hit.
    PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1.

    Entry informationi

    Entry nameiUNG_SHEON
    AccessioniPrimary (citable) accession number: Q8EB78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3