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Q8EAF7

- MURA_SHEON

UniProt

Q8EAF7 - MURA_SHEON

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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Gene

murA

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Proton donorUniRule annotation

GO - Molecular functioni

  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
  6. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferaseUniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferaseUniRule annotation
Short name:
EPTUniRule annotation
Gene namesi
Name:murAUniRule annotation
Ordered Locus Names:SO_3948
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419UDP-N-acetylglucosamine 1-carboxyvinyltransferasePRO_0000231260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 11712-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_3948.

Structurei

3D structure databases

ProteinModelPortaliQ8EAF7.
SMRiQ8EAF7. Positions 1-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIEIGEDW.
OrthoDBiEOG68M4GK.
PhylomeDBiQ8EAF7.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EAF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKLAIQASP PLAGDVIISG AKNAALPILM AGVLAETDFV VSNVPNLRDV
60 70 80 90 100
STSCKLLRCL GADVDELGEG KIRISTKNLN EFCAPYDLVK TMRASILILG
110 120 130 140 150
PLLARYGTAD VSLPGGCAIG ARPVNLHLHG LEMMGAKIEV KEGYIKARVD
160 170 180 190 200
GRLKGAHIFM DMVSVGATEN LLMAAALADG ETVIENAARE PEVIDLANCL
210 220 230 240 250
IAMGAKITGV GSATLRIQGV ERLQGCEYRV MPDRIETGSF LVAAAVTRGR
260 270 280 290 300
IRCLKADPAS LESVIAKLED AGAKITTGED WIELDMEGKR PKAVNIKTAP
310 320 330 340 350
YPGFPTDMQA QFCVLNVLAQ GTATITETIF ENRFMHVPEL IRMGATMELE
360 370 380 390 400
GNTCIIQGIE SLSGAQVMAT DLRASASLVI AGLVADGKTI VDRIYHLDRG
410
YEHIEQKFQG LGAHVERVQ
Length:419
Mass (Da):44,766
Last modified:March 1, 2003 - v1
Checksum:i27C7765124006D6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN56922.1.
RefSeqiNP_719478.1. NC_004347.2.
WP_011073687.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN56922; AAN56922; SO_3948.
GeneIDi1171585.
KEGGison:SO_3948.
PATRICi23527576. VBISheOne101494_3832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN56922.1 .
RefSeqi NP_719478.1. NC_004347.2.
WP_011073687.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EAF7.
SMRi Q8EAF7. Positions 1-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_3948.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN56922 ; AAN56922 ; SO_3948 .
GeneIDi 1171585.
KEGGi son:SO_3948.
PATRICi 23527576. VBISheOne101494_3832.

Phylogenomic databases

eggNOGi COG0766.
HOGENOMi HOG000075602.
KOi K00790.
OMAi IEIGEDW.
OrthoDBi EOG68M4GK.
PhylomeDBi Q8EAF7.

Enzyme and pathway databases

UniPathwayi UPA00219 .

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00111. MurA.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view ]
PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01072. murA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiMURA_SHEON
AccessioniPrimary (citable) accession number: Q8EAF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3