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Q8EAF7 (MURA_SHEON) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT
Gene names
Name:murA
Ordered Locus Names:SO_3948
OrganismShewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP]
Taxonomic identifier211586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
PRO_0000231260

Sites

Active site1171Proton donor By similarity

Amino acid modifications

Modified residue11712-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EAF7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 27C7765124006D6B

FASTA41944,766
        10         20         30         40         50         60 
MDKLAIQASP PLAGDVIISG AKNAALPILM AGVLAETDFV VSNVPNLRDV STSCKLLRCL 

        70         80         90        100        110        120 
GADVDELGEG KIRISTKNLN EFCAPYDLVK TMRASILILG PLLARYGTAD VSLPGGCAIG 

       130        140        150        160        170        180 
ARPVNLHLHG LEMMGAKIEV KEGYIKARVD GRLKGAHIFM DMVSVGATEN LLMAAALADG 

       190        200        210        220        230        240 
ETVIENAARE PEVIDLANCL IAMGAKITGV GSATLRIQGV ERLQGCEYRV MPDRIETGSF 

       250        260        270        280        290        300 
LVAAAVTRGR IRCLKADPAS LESVIAKLED AGAKITTGED WIELDMEGKR PKAVNIKTAP 

       310        320        330        340        350        360 
YPGFPTDMQA QFCVLNVLAQ GTATITETIF ENRFMHVPEL IRMGATMELE GNTCIIQGIE 

       370        380        390        400        410 
SLSGAQVMAT DLRASASLVI AGLVADGKTI VDRIYHLDRG YEHIEQKFQG LGAHVERVQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014299 Genomic DNA. Translation: AAN56922.1.
RefSeqNP_719478.1. NC_004347.2.

3D structure databases

ProteinModelPortalQ8EAF7.
SMRQ8EAF7. Positions 1-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING211586.SO_3948.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN56922; AAN56922; SO_3948.
GeneID1171585.
KEGGson:SO_3948.
PATRIC23527576. VBISheOne101494_3832.

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAGYEHIED.
OrthoDBEOG68M4GK.
ProtClustDBPRK09369.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA_SHEON
AccessionPrimary (citable) accession number: Q8EAF7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways