Q8EA43 (PUR7_SHEON) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	SO_4066

Organism

Shewanella oneidensis

Taxonomic identifier

70863 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_0000100867

Sequences

	Sequence		Length	Mass (Da)
	Q8EA43 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 95D389F1C4797BAB	FASTA	367	40,902
	10 20 30 40 50 60 MSLADSVLAV NNDLPIRTDK SVHSGKVRSV YWLTDADSRR LIKTKGYNVP EDTPLAIMVI 70 80 90 100 110 120 SDRISAFDCI FHGEGGLKGI PGKGAALNAI SNHWFKLFAE NGLADSHILD IPHPFVWIVQ 130 140 150 160 170 180 KARPIKVEAI CRQYITGSMW RAYSKGERVF CGITLPEGLE KDQKLPELLI TPSTKGILTG 190 200 210 220 230 240 IPGVPAQDDV NISRSDIEAN YQAFGFEKVE DIDLYEKLLK DGFKVISKAL ADLDQVFVDT 250 260 270 280 290 300 KFEFGYVTDQ DGNSKLIYMD EVGTPDSSRI WDGAAYRDGK ILENSKEGFR QFLLNHFPDP 310 320 330 340 350 360 DILLNKDRMP EREALARDNA LPLEAMMQVS RTYTGIAEKV TGAAIPLPAN PKADIIKILR EEYDLIV

References

[1]

"Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis." Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C., Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T. , Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C., Nealson K.H., Fraser C.M. Nat. Biotechnol. 20:1118-1123(2002) [PubMed: 12368813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014299 Genomic DNA. Translation: AAN57040.1.
RefSeq	NP_719596.1. NC_004347.1.
3D structure databases
ProteinModelPortal	Q8EA43.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1171687.
GenomeReviews	Gene locus SO_4066 in contig AE014299_GR.
KEGG	son:SO_4066.
NMPDR	fig|211586.1.peg.3688.
PATRIC	23527784. VBISheOne101494_3936.
TIGR	SO_4066.
Phylogenomic databases
HOGENOM	HBG555040.
OMA	SSRIWDG.
ProtClustDB	PRK13960.
Enzyme and pathway databases
BioCyc	SONE211586:SO_4066-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_SHEON

Accession

Primary (citable) accession number: Q8EA43

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program