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Q8E9L6

- GCH1_SHEON

UniProt

Q8E9L6 - GCH1_SHEON

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Protein
GTP cyclohydrolase 1
Gene
folE, SO_4254
Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi108 – 1081Zinc By similarity
Metal bindingi111 – 1111Zinc By similarity
Metal bindingi179 – 1791Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:SO_4254
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216GTP cyclohydrolase 1UniRule annotation
PRO_0000119442Add
BLAST

Proteomic databases

PRIDEiQ8E9L6.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Protein-protein interaction databases

STRINGi211586.SO_4254.

Structurei

3D structure databases

ProteinModelPortaliQ8E9L6.
SMRiQ8E9L6. Positions 3-212.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiVQFFSSR.
OrthoDBiEOG6XHC8G.
PhylomeDBiQ8E9L6.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8E9L6-1 [UniParc]FASTAAdd to Basket

« Hide

MPLSEAAVKV QAALQERGLE TPMLPSVFTP EERKDKIEHH MKEILTLMSL    50
DLSDDSLADT PRRIAKMYVD EIFSGLDYAN FPKITVIDNK MGFDEMVRVQ 100
DISLTSTCEH HLVTIDGTAT IAYLPRKKII GLSKINRIVR FFAQRPQVQE 150
RLTQQVLVAL QTLLETKDVA VKMDAVHYCV KSRGVMDSTS STTTTALGGI 200
FKSNPATRAE FLHQSK 216
Length:216
Mass (Da):24,223
Last modified:March 1, 2003 - v1
Checksum:i2857CC6E1EF91BB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN57225.1.
RefSeqiNP_719781.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN57225; AAN57225; SO_4254.
GeneIDi1171857.
KEGGison:SO_4254.
PATRICi23528148. VBISheOne101494_4113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN57225.1 .
RefSeqi NP_719781.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8E9L6.
SMRi Q8E9L6. Positions 3-212.
ModBasei Search...

Protein-protein interaction databases

STRINGi 211586.SO_4254.

Proteomic databases

PRIDEi Q8E9L6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN57225 ; AAN57225 ; SO_4254 .
GeneIDi 1171857.
KEGGi son:SO_4254.
PATRICi 23528148. VBISheOne101494_4113.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi VQFFSSR.
OrthoDBi EOG6XHC8G.
PhylomeDBi Q8E9L6.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiGCH1_SHEON
AccessioniPrimary (citable) accession number: Q8E9L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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