Reviewed, UniProtKB/Swiss-Prot Q8E9K1 (UPPP2_SHEON)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Synonyms:	bacA2, upk2
Ordered Locus Names:	SO_4274

Organism

Shewanella oneidensis [Complete proteome] [HAMAP]

Taxonomic identifier

70863 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151195
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	43 – 63	21	Potential
	Transmembrane	84 – 104	21	Potential
	Transmembrane	109 – 129	21	Potential
	Transmembrane	147 – 167	21	Potential
	Transmembrane	186 – 206	21	Potential
	Transmembrane	219 – 239	21	Potential
	Transmembrane	243 – 263	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8E9K1-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 71AB1A0637EA3D15	FASTA	267	29,158
	10 20 30 40 50 60 MDLIYFIKAF FLGVIEGITE FLPISSTGHL ILIGDWINFS SNEEKVFEVV IQLGGILAVC 70 80 90 100 110 120 WLFRDKIINL INGVLKSDPV AQRFAVIVMI SFLPSAIIGA LFIHDIKNVL FNTTVVATAL 130 140 150 160 170 180 IVGGLIILWV ENRKDSEKFK IENIEKIGFK QAIIIGIAQC IAMIPGTSRS GATIVGGMLS 190 200 210 220 230 240 GVSRKAATEY SFFLAIPTML GAAIYDASKN YHLLNTDDIL AILIGFSAAF ISALIVVNAL 250 260 IRFVAKHSLS VFAWYRIALG LIIFSVN

References

[1]

"Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis." Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C., Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T. , Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C., Nealson K.H., Fraser C.M. Nat. Biotechnol. 20:1118-1123(2002) [PubMed: 12368813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014299 Genomic DNA. Translation: AAN57243.1.
RefSeq	NP_719799.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1171875.
GenomeReviews	Gene locus SO_4274 in contig AE014299_GR.
KEGG	son:SO_4274.
NMPDR	fig|211586.1.peg.3876.
TIGR	SO_4274.
Phylogenomic databases
HOGENOM	Q8E9K1.
OMA	KPFAYYR.
Enzyme and pathway databases
BioCyc	SONE211586:SO_4274-MON.
BRENDA	3.6.1.27. 257422.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_SHEON

Accession

Primary (citable) accession number: Q8E9K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)