ID   Q8E9H1_SHEON            Unreviewed;       804 AA.
AC   Q8E9H1;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE   AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE   AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN   Name=cyaA {ECO:0000313|EMBL:AAN57281.1};
GN   OrderedLocusNames=SO_4312 {ECO:0000313|EMBL:AAN57281.1};
OS   Shewanella oneidensis (strain MR-1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=211586 {ECO:0000313|EMBL:AAN57281.1, ECO:0000313|Proteomes:UP000008186};
RN   [1] {ECO:0000313|EMBL:AAN57281.1, ECO:0000313|Proteomes:UP000008186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-1 {ECO:0000313|EMBL:AAN57281.1,
RC   ECO:0000313|Proteomes:UP000008186};
RX   PubMed=12368813; DOI=10.1038/nbt749;
RA   Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA   Read T.D., Eisen J.A., Seshadri R., Ward N., Methe B., Clayton R.A.,
RA   Meyer T., Tsapin A., Scott J., Beanan M., Brinkac L., Daugherty S.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA   Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J., Weidman J.,
RA   Impraim M., Lee K., Berry K., Lee C., Mueller J., Khouri H., Gill J.,
RA   Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C.,
RA   Nealson K.H., Fraser C.M.;
RT   "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT   Shewanella oneidensis.";
RL   Nat. Biotechnol. 20:1118-1123(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; AE014299; AAN57281.1; -; Genomic_DNA.
DR   RefSeq; NP_719837.1; NC_004347.2.
DR   RefSeq; WP_011073971.1; NZ_CP053946.1.
DR   AlphaFoldDB; Q8E9H1; -.
DR   STRING; 211586.SO_4312; -.
DR   PaxDb; 211586-SO_4312; -.
DR   KEGG; son:SO_4312; -.
DR   PATRIC; fig|211586.12.peg.4175; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   PhylomeDB; Q8E9H1; -.
DR   BioCyc; SONE211586:G1GMP-3983-MONOMER; -.
DR   Proteomes; UP000008186; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 2.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:AAN57281.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008186}.
FT   DOMAIN          10..202
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   804 AA;  92445 MW;  2CA3C230F766B7C3 CRC64;
     MDQQGHFPDI AERLNQVRIA RALALLSPLQ KHLFRLIPFL IQQNSVQYPG FVDPNTPCGI
     YGYKAGSLEA QACDVFKLPF IATEVDFYAF EGVYAMGSTA SFGQNAKSDV DVWLVHHADL
     CDDDLALIKL KTERLTAWFA EYQFEVNFYL VHPLQFCGDM SQRTVCQSSM AHEHSGSTQH
     WLLLEEFYRS QIRLAGKIIA WWPDAKLNPE LLSLGNVHEL PASEYFGASL WQLYKGLNKP
     HKALIKVLLL EAYASEYPHS QLLCDRLWQK TLAGDFSTAN DAYYAIYEVI EAYLLKQNDS
     RRLEIVRRCF YLKCGVFLSL SNQGKDWRYA KMQKLVQEWQ WPNSLITTLD DCEHWHSGQL
     NWFNEQLNEL LLASYQTLLR FASTHELNEG LKIEELGMLT RKLHTYFSQD EDQIAKLNLL
     WSRSVAEAEV TMVSSTKENQ YYLYRQGPKP LNLLGDSAIC KGKSPSALMI WACLNGVSTP
     ETKWYEFGQS KVKSQRLTDA SKRLLNFIDH DWRVSKLDLC QPWHFRKLIF ILNLDCDPTI
     GWRGQEMMVD VMNANVFSLG RKQENMLGAL DAICLNSWGE WQCHRFEGET AVLQALAFVT
     PGLRRATHPV DMDVISCSQR LRPQLKLAVK NLLKQTVRLC QQVQQSSTLV QPLQISHTRY
     GIFFNPLGMA YQDLSDAKSF YQQLARSHLV QLPRPELGDD PFSSMPNIIQ NFAAKGAIQY
     FLRQRTDSLD VFILDEENQL SHYVQSGSDM SELVNKVSHH YVFDEFYASK ARFNIPQFFH
     LVRVAGELTV RPFGVDMNNA NVEF
//