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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Transition state stabilizerUniRule annotation
Active sitei98 – 981Proton acceptorUniRule annotation
Metal bindingi266 – 2661Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2660. SonCP02.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:SO_4405
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222UniRule annotationAdd
BLAST
Chaini23 – 728706Catalase-peroxidase 1PRO_0000354920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki97 ↔ 225Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-251)UniRule annotation
Cross-linki225 ↔ 251Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PaxDbiQ8E981.
PRIDEiQ8E981.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi211586.SO_4405.

Structurei

3D structure databases

ProteinModelPortaliQ8E981.
SMRiQ8E981. Positions 27-727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiEOG6RRKKM.
PhylomeDBiQ8E981.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8E981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKTQRSQGK CPVMHGANSA VASNNMDWWP KALNLDILHQ HDQKTDPMDP
60 70 80 90 100
NFSYRDAFNS LDLAAVKQDL HSLMTDSQDW WPADWGHYGG LMIRMAWHSA
110 120 130 140 150
GTYRIADGRG GAGTGNQRFA PLNSWPDNAN LDKARRLLWP IKKKYGNKLS
160 170 180 190 200
WADLIILAGN VAYESMGLKT FGFAGGRADI WHPEKDIYWG SEKQWLAPSD
210 220 230 240 250
NPNSRYSGAR DLENPLAAVM MGLIYVNPEG VDGKPDPLRT AQDVRITFAR
260 270 280 290 300
MAMDDEETVA LTAGGHTVGK CHGNGKAQDL GPEPEGEDVE AQGLGWLNKK
310 320 330 340 350
GRGVGCDAVT SGLEGAWTTH PTQWDNGYFY LLLNYDWELK KSPAGAWQWE
360 370 380 390 400
PINIKEEDKV ISVGDPAKKF NPIMTDADMA MKIDPEYRKI SERFYQDPAY
410 420 430 440 450
FSEVFARAWF KLTHRDLGPK SRYLGPEVPS EELIWQDPIP SVDYRLVASE
460 470 480 490 500
IVELKAKLLA SGLSVSELVA TAWDSARTFR GSDFRGGANG ARIRLAPQKD
510 520 530 540 550
WSGNEPERLQ KVLKVLSALQ ASLSKKVSIA DLIVLGGAAA IEKAAHAAGV
560 570 580 590 600
NITVPFMPGR GDATKEMTDV ESFVVLEPLH DAYRNWLKQD YVVQPEEMML
610 620 630 640 650
DRSQLMGLTA HEMTVLIGGM RVLGTNHGGT RHGVFTDKVG VLSNDFFVNL
660 670 680 690 700
TDMAYSWKPV GTNLYEVVER KTGTVKWTAT RVDLVFGSNS VLRVYAEVYA
710 720
QDDAKEKFVH DFVAAWTKVM NADRFDLA
Length:728
Mass (Da):80,981
Last modified:March 1, 2003 - v1
Checksum:i354F1B25226EF0E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN57372.1.
RefSeqiNP_719928.1. NC_004347.2.
WP_011074054.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN57372; AAN57372; SO_4405.
GeneIDi1172005.
KEGGison:SO_4405.
PATRICi23528467. VBISheOne101494_4268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN57372.1.
RefSeqiNP_719928.1. NC_004347.2.
WP_011074054.1. NC_004347.2.

3D structure databases

ProteinModelPortaliQ8E981.
SMRiQ8E981. Positions 27-727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211586.SO_4405.

Protein family/group databases

PeroxiBasei2660. SonCP02.

Proteomic databases

PaxDbiQ8E981.
PRIDEiQ8E981.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN57372; AAN57372; SO_4405.
GeneIDi1172005.
KEGGison:SO_4405.
PATRICi23528467. VBISheOne101494_4268.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiEOG6RRKKM.
PhylomeDBiQ8E981.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiKATG1_SHEON
AccessioniPrimary (citable) accession number: Q8E981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.