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Q8E6A9 (LDHD_STRA3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-lactate dehydrogenase
Short name=D-LDH
EC=1.1.1.28
Alternative name(s):
D-specific D-2-hydroxyacid dehydrogenase
Gene names
Name:ldhD
Ordered Locus Names:gbs0668
OrganismStreptococcus agalactiae serotype III [Complete proteome] [HAMAP]
Taxonomic identifier216495 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-lactate + NAD+ = pyruvate + NADH.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionD-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330D-lactate dehydrogenase
PRO_0000075968

Regions

Nucleotide binding155 – 1562NAD By similarity
Nucleotide binding233 – 2353NAD By similarity
Nucleotide binding296 – 2994NAD By similarity

Sites

Active site2351 By similarity
Active site2641 By similarity
Active site2961Proton donor By similarity
Binding site2591NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8E6A9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 1E639C912B4A46B5

FASTA33036,501
        10         20         30         40         50         60 
MKLKVFNVRE EEATLAQDWA NRNHVELSMS EGPLTLETVN EVEGFDGIAN AQIGPLDDAI 

        70         80         90        100        110        120 
YPLLKEMGIK QIAQRSAGVD MYNLELAKQH GIIISNVPSY SPESIAEFTV TIALNLIRKV 

       130        140        150        160        170        180 
ELIRANVREQ NFSWTLPIRG RVLGNMTVAI IGTGRIGLAT AKIFKGFGCR VIGYDIYHNP 

       190        200        210        220        230        240 
MADGILEYVN SVEEAVEKAD LVSLHMPPTA ENTHLFNLDM FKQFKKGAIL MNMARGALVE 

       250        260        270        280        290        300 
TKDLLEALDQ GLLEGAGIDT YEFEGPYIPK NCQGQDISDK DFLRLINHPK VIYTPHAAYY 

       310        320        330 
TDEAVKNLVE GALNACVEVV ETGTTTTRVN

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References

[1]"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NEM316 / Serotype III.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL766846 Genomic DNA. Translation: CAD46312.1.
RefSeqNP_735118.1. NC_004368.1.

3D structure databases

ProteinModelPortalQ8E6A9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000002173; EBSTRP00000002091; EBSTRG00000002173.
GeneID1031708.
GenomeReviewsGene locus gbs0668 in contig AL732656_GR.
KEGGsan:gbs0668.
PATRIC19637190. VBIStrAga3577_0687.

Organism-specific databases

GenoListgbs0668.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000027840.
HOGENOMHBG731446.
OMAERESAYF.
ProtClustDBPRK08605.

Enzyme and pathway databases

BioCycSAGA211110:GBS0668-MONOMER.

Family and domain databases

InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KOK03778.
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. False negative.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDHD_STRA3
AccessionPrimary (citable) accession number: Q8E6A9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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