Q8E6A2 (UXUA_STRA3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	gbs0675

Organism

Streptococcus agalactiae serotype III [Complete proteome] [HAMAP]

Taxonomic identifier

216495 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Mannonate dehydratase HAMAP MF_00106		PRO_0000170687

Sequences

	Sequence		Length	Mass (Da)
	Q8E6A2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2D135E69A7C9C4DA	FASTA	348	39,263
	10 20 30 40 50 60 MEMSFRWYGE DDPVTLENIG QIPTMKGIVT AIYDVPVGEV WSRERIQQLK EKVEAAGLKI 70 80 90 100 110 120 SVIESVPVHE DIKLGRPTRD LLIDNYIQTV KNLAAEGIDT ICYNFMPVFD WTRTDLAYQY 130 140 150 160 170 180 PDGSTALIFD ETVSKKMDPV NGELSLPGWD ASYSKEEMKA IMDAYAEIDE EKLWENLTYF 190 200 210 220 230 240 IKRIIPEAEA VGVKMAIHPD DPPYSIFGLP RIITGLEAIE RFVKLYDSKS NGITLCVGSY 250 260 270 280 290 300 ASDPQNDVLE ISRRAFELDR VNFVHARNIK LGDGKSFKES AHPSEYGSID MYEVIKLCHE 310 320 330 340 FGFEGAIRPD HGRMIWGETG RPGYGLYDRA LGATYLSGLY EAVIKGSK

References

[1]

"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease." Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F. Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NEM316 / Serotype III.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL766846 Genomic DNA. Translation: CAD46319.1.
RefSeq	NP_735125.1. NC_004368.1.
3D structure databases
ProteinModelPortal	Q8E6A2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000002562; EBSTRP00000002480; EBSTRG00000002562.
GeneID	1031717.
GenomeReviews	Gene locus gbs0675 in contig AL732656_GR.
KEGG	san:gbs0675.
PATRIC	19637206. VBIStrAga3577_0695.
Organism-specific databases
GenoList	gbs0675.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000026584.
HOGENOM	HBG585927.
OMA	DIKLGKP.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	SAGA211110:GBS0675-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_STRA3

Accession

Primary (citable) accession number: Q8E6A2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program