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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei594 – 5941UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:gbs0780
OrganismiStreptococcus agalactiae serotype III (strain NEM316)
Taxonomic identifieri211110 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000823: Chromosome

Organism-specific databases

GenoListigbs0780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Phosphoenolpyruvate carboxylasePRO_0000166625Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211110.gbs0780.

Structurei

3D structure databases

ProteinModelPortaliQ8E647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 2 hits.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8E647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPKLESSS NKEIITEEVG LLKQLLDEAT QKLIGSESFD KIEKIVSLSL
60 70 80 90 100
TDDYTGLKET ISALSNEEMV IVSRYFSILP LLINISEDVD LAYEINYKNN
110 120 130 140 150
LNQDYLGKLS TTIDVVAGHE NAKDILEHVN VVPVLTAHPT QVQRKTVLEL
160 170 180 190 200
TSKIHDLLRK YRDVKAGIVN QEKWYADLRR YIGIIMQTDT IREKKLKVKN
210 220 230 240 250
EITNVMEYYN RSLIKAVTKL TAEYKALAAK KGIHLENPKP LTMGMWIGGD
260 270 280 290 300
RDGNPFVTAE TLRLSAMVQS EVIINHYIEQ LNELYRNMSL SINLTEVSPE
310 320 330 340 350
LVTLANQSQD NSVYRENEPY RKAFNFIQDK LVQTLLNLKV GSSPKEKFVS
360 370 380 390 400
RQESSDIVGR YIKSHIAQVA SDIQTEELPA YATAEEFKQD LLLVKQSLVQ
410 420 430 440 450
YGQDSLVDGE LACLIQAVDI FGFYLATIDM RQDSSINEAC VAELLKSANI
460 470 480 490 500
VDDYSSLSEE EKCQLLLKEL TEDPRTLSST HAPKSELLQK ELAIFQTARE
510 520 530 540 550
LKDQLGEDII NQHIISHTES VSDMFELAIM LKEVGLIDAN QARIQIVPLF
560 570 580 590 600
ETIEDLDNSR DIMTQYLHYE LVKKWIATNN NYQEIMLGYS DSNKDGGYLS
610 620 630 640 650
SGWTLYKAQN ELTKIGEENG IKITFFHGRG GTVGRGGGPS YEAITSQPFG
660 670 680 690 700
SIKDRIRLTE QGEIIENKYG NQDAAYYNLE MLISASIDRM VTRMITNPNE
710 720 730 740 750
IDNFRETMDG IVSESNAVYR NLVFDNPYFY DYFFEASPIK EVSSLNIGSR
760 770 780 790 800
PAARKTITEI SGLRAIPWVF SWSQNRIMFP GWYGVGSAFK HFIEQDEANL
810 820 830 840 850
AKLQTMYQKW PFFNSLLSNV DMVLSKSNMN IALQYAQLAG SKEVRDVFNI
860 870 880 890 900
ILNEWQLTKD MILAIEQHDN LLEENPMLHA SLDYRLPYFN VLNYVQIELI
910 920 930
KRLRSNQLDE DYEKLIHITI NGIATGLRNS G
Length:931
Mass (Da):105,962
Last modified:March 1, 2003 - v1
Checksum:iF5338365FADF9B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL766847 Genomic DNA. Translation: CAD46424.1.
RefSeqiNP_735230.1. NC_004368.1.

Genome annotation databases

EnsemblBacteriaiCAD46424; CAD46424; CAD46424.
GeneIDi1031917.
KEGGisan:gbs0780.
PATRICi19637420. VBIStrAga3577_0802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL766847 Genomic DNA. Translation: CAD46424.1.
RefSeqiNP_735230.1. NC_004368.1.

3D structure databases

ProteinModelPortaliQ8E647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211110.gbs0780.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD46424; CAD46424; CAD46424.
GeneIDi1031917.
KEGGisan:gbs0780.
PATRICi19637420. VBIStrAga3577_0802.

Organism-specific databases

GenoListigbs0780.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 2 hits.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
    Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
    Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NEM316.

Entry informationi

Entry nameiCAPP_STRA3
AccessioniPrimary (citable) accession number: Q8E647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.