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Q8E5U1

- SYFB_STRA3

UniProt

Q8E5U1 - SYFB_STRA3

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Protein
Phenylalanine--tRNA ligase beta subunit
Gene
pheT, gbs0888
Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Binds 2 magnesium ions per tetramer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi459 – 4591Magnesium By similarity
Metal bindingi465 – 4651Magnesium; via carbonyl oxygen By similarity
Metal bindingi468 – 4681Magnesium By similarity
Metal bindingi469 – 4691Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
  2. tRNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
Gene namesi
Name:pheT
Ordered Locus Names:gbs0888
OrganismiStreptococcus agalactiae serotype III (strain NEM316)
Taxonomic identifieri211110 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000823: Chromosome

Organism-specific databases

GenoListigbs0888.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 801801Phenylalanine--tRNA ligase beta subunitUniRule annotation
PRO_0000126957Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi211110.gbs0888.

Structurei

3D structure databases

ProteinModelPortaliQ8E5U1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 153115tRNA-binding
Add
BLAST
Domaini406 – 48176B5
Add
BLAST
Domaini708 – 80194FDX-ACB
Add
BLAST

Sequence similaritiesi

Contains 1 B5 domain.
Contains 1 FDX-ACB domain.

Phylogenomic databases

eggNOGiCOG0072.
HOGENOMiHOG000292087.
KOiK01890.
OMAiNYVMIEL.
OrthoDBiEOG6CCH1J.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPiMF_00283. Phe_tRNA_synth_beta1.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsiTIGR00472. pheT_bact. 1 hit.
PROSITEiPS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8E5U1-1 [UniParc]FASTAAdd to Basket

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MLVSYKWLKE LVDVDVTTAE LAEKMSTTGI EVEGVETPAE GLSKLVVGHI    50
VSCEDVPDTH LHLCQVDTGD DELRQVVCGA PNVKTGINVI VAVPGARIAD 100
NYKIKKGKIR GMESLGMICS LQELGLSESI IPKEFSDGIQ ILPEGAIPGD 150
SIFSYLDLDD EIIELSITPN RADALSMRGV AHEVAAIYGK KVHFEEKNLI 200
EEAERAADKI SVVIESDKVL SYSARIVKNV TVAPSPQWLQ NKLMNAGIRP 250
INNVVDVTNY VLLTYGQPMH AFDFDKFDGT TIVARNAENG EKLITLDGEE 300
RDLIADDLVI AVNDQPVALA GVMGGQSTEI GSSSKTVVLE AAVFNGTSIR 350
KTSGRLNLRS ESSSRFEKGI NYDTVSEAMD FAAAMLQELA GGQVLSGQVT 400
EGVLPTEPVE VSTTLGYVNT RLGTELTYTD IEEVFEKLGF AISGSEVKFT 450
VLVPRRRWDI AIQADLVEEI ARIYGYEKLP TTLPEAGATA GELTSMQRLR 500
RRVRTVAEGA GLSEIITYAL TTPEKAVQFS TQATNITELM WPMTVDRSAL 550
RQNVVSGMLD TIAYNVARKN SNLAVYEIGK VFEQTGNPKE DLPTEVETFT 600
FALTGLVEEK DFQTKAKPVD FFYAKGIVEA LFIKLKLDVT FVAQKGLASM 650
HPGRTATILL DGKEIGFVGQ VHPQTAKQYD IPETYVAEIN LSTIESQMNQ 700
ALIFEDITKY PSVSRDIALL LAESVSHHDI VSAIETSGVK RLTAIKLFDV 750
YAGNNIAEGY KSMAYSLTFQ NPNDNLTDEE VAKYMEKITK SLVEKVNAEI 800
R 801
Length:801
Mass (Da):87,622
Last modified:March 1, 2003 - v1
Checksum:iD0E776E9D0084CEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL766847 Genomic DNA. Translation: CAD46532.1.
RefSeqiNP_735338.1. NC_004368.1.

Genome annotation databases

EnsemblBacteriaiCAD46532; CAD46532; CAD46532.
GeneIDi1029872.
KEGGisan:gbs0888.
PATRICi19637640. VBIStrAga3577_0912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL766847 Genomic DNA. Translation: CAD46532.1 .
RefSeqi NP_735338.1. NC_004368.1.

3D structure databases

ProteinModelPortali Q8E5U1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 211110.gbs0888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD46532 ; CAD46532 ; CAD46532 .
GeneIDi 1029872.
KEGGi san:gbs0888.
PATRICi 19637640. VBIStrAga3577_0912.

Organism-specific databases

GenoListi gbs0888.

Phylogenomic databases

eggNOGi COG0072.
HOGENOMi HOG000292087.
KOi K01890.
OMAi NYVMIEL.
OrthoDBi EOG6CCH1J.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPi MF_00283. Phe_tRNA_synth_beta1.
InterProi IPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view ]
Pfami PF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsi TIGR00472. pheT_bact. 1 hit.
PROSITEi PS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
    Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
    Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NEM316.

Entry informationi

Entry nameiSYFB_STRA3
AccessioniPrimary (citable) accession number: Q8E5U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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