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Q8E5P8

- GLMS_STRA3

UniProt

Q8E5P8 - GLMS_STRA3

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei599 – 5991For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:gbs0933
    OrganismiStreptococcus agalactiae serotype III (strain NEM316)
    Taxonomic identifieri211110 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    Organism-specific databases

    GenoListigbs0933.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135387Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi211110.gbs0933.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8E5P8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini284 – 423140SIS 1UniRule annotationAdd
    BLAST
    Domaini456 – 594139SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8E5P8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGVVGN TNATDILIQG LEKLEYRGYD SAGIFVVGDN KSQLVKSVGR    50
    IAELQAKVGD SVSGTTGIGH TRWATHGKPT EGNAHPHTSG SGRFVLVHNG 100
    VIENYLQIKE TYLTKHNLKG ETDTEIAIHL VEHFVEEDNL SVLEAFKKAL 150
    HIIEGSYAFA LIDSQDADTI YVAKNKSPLL IGLGNGYNMV CSDAMAMIRE 200
    TSEYMEIHDK ELVIVKKDSV EVQDYDGNVI ERGSYTAELD LSDIGKGTYP 250
    FYMLKEIDEQ PTVMRKLIST YANESGDMNV DSDIIKSVQE ADRLYILAAG 300
    TSYHAGFAAK TMIEKLTDTP VELGVSSEWG YNMPLLSKKP MFILLSQSGE 350
    TADSRQVLVK ANEMGIPSLT ITNVPGSTLS REATYTMLIH AGPEIAVAST 400
    KAYTAQVATL AFLAKAVGEA NGKAEAKDFD LVHELSIVAQ SIEATLSEKD 450
    VISEKVEQLL ISTRNAFYIG RGNDYYVTME AALKLKEISY IQTEGFAAGE 500
    LKHGTISLIE DNTPVIALIS ADSTIAAHTR GNIQEVVSRG ANALIIVEEG 550
    LEREGDDIIV NKVHPFLSAI SMVIPTQLIA YYASLQRGLD VDKPRNLAKA 600
    VTVE 604
    Length:604
    Mass (Da):65,636
    Last modified:January 23, 2007 - v3
    Checksum:i1342FAF91B474081
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL766848 Genomic DNA. Translation: CAD46592.1.
    RefSeqiNP_735382.1. NC_004368.1.

    Genome annotation databases

    EnsemblBacteriaiCAD46592; CAD46592; CAD46592.
    GeneIDi1029918.
    KEGGisan:gbs0933.
    PATRICi19637732. VBIStrAga3577_0958.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL766848 Genomic DNA. Translation: CAD46592.1 .
    RefSeqi NP_735382.1. NC_004368.1.

    3D structure databases

    ProteinModelPortali Q8E5P8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211110.gbs0933.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD46592 ; CAD46592 ; CAD46592 .
    GeneIDi 1029918.
    KEGGi san:gbs0933.
    PATRICi 19637732. VBIStrAga3577_0958.

    Organism-specific databases

    GenoListi gbs0933.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
      Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
      Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NEM316.

    Entry informationi

    Entry nameiGLMS_STRA3
    AccessioniPrimary (citable) accession number: Q8E5P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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