Reviewed, UniProtKB/Swiss-Prot Q8E5J8 (SPX_STRA3)

Names and origin

Protein names

Recommended name:
    Regulatory protein spx

Gene names

Name:	spxA
Ordered Locus Names:	gbs1031

Organism

Streptococcus agalactiae serotype III [Complete proteome] [HAMAP]

Taxonomic identifier

216495 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the arsC family. Spx subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription regulator activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Regulatory protein spx HAMAP MF_01132		PRO_0000162572
Amino acid modifications
	Disulfide bond	10 ↔ 13		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8E5J8-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: C4E37AD89D60F6BC	FASTA	137	15,846
	10 20 30 40 50 60 MITLFLSPSC TSCRKARAWL SKHEVAFEEH NIITSPLNKE ELLQILSFTE NGTEDIISTR 70 80 90 100 110 120 SKVFQKLAID VDELSTSSLM ELISENPSLL RRPIILDKKR MQIGFNEDEI RAFLPRDYRK 130 QELKQATIRA EIEGKHD

References

[1]

"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease." Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F. Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NEM316 / Serotype III.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL766848 Genomic DNA. Translation: CAD46690.1.
RefSeq	NP_735480.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1030028.
GenomeReviews	Gene locus gbs1031 in contig AL732656_GR.
KEGG	san:gbs1031.
Organism-specific databases
SagaList	gbs1031.
CMR	Search...
Phylogenomic databases
HOGENOM	Q8E5J8.
OMA	Q8E5J8. FTERNIF.
Enzyme and pathway databases
BioCyc	SAGA211110:GBS1031-MON.
Family and domain databases
HAMAP	MF_01132. [Tree]
InterPro	IPR006660. Arsenate_reductase-like. IPR006504. CHP1617_ArsC_rel. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01617. arsC_related. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPX_STRA3

Accession

Primary (citable) accession number: Q8E5J8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)