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Q8E568 (KPRS2_STRA3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase 2
Short name=RPPK 2
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 2
Short name=P-Rib-PP synthase 2
Short name=PRPP synthase 2
Gene names
Name:prs2
Ordered Locus Names:gbs1164
OrganismStreptococcus agalactiae serotype III (strain NEM316) [Complete proteome] [HAMAP]
Taxonomic identifier211110 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583_B

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583_B

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Ribose-phosphate pyrophosphokinase 2 HAMAP-Rule MF_00583_B
PRO_0000141197

Regions

Region218 – 23114Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1341Magnesium Potential
Metal binding1361Magnesium Potential
Metal binding1451Magnesium Potential
Metal binding1491Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q8E568 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B0AFB817350DFBBE

FASTA32435,689
        10         20         30         40         50         60 
MAEQYADKQI KLFSLTANRE IAEKISQASG IPLGKMSSRQ FSDGEIMINI EETVRGDDIY 

        70         80         90        100        110        120 
IIQSTSFPVN DNLWELLIMI DACKRASANT VNIVVPYFGY SRQDRIAASR EPITAKLVAN 

       130        140        150        160        170        180 
MLVKAGVDRV LTLDLHAVQV QGFFDIPVDN LFTVPLFAEH YNQLGLSGED VVVVSPKNSG 

       190        200        210        220        230        240 
IKRARSLAEY LDSPIAIIDY AQDDSEREEG YIIGEVEGKK AIIIDDILNT GKTFAEAAKI 

       250        260        270        280        290        300 
LERGGATEIY AVASHGLFAG GAADILESAP IREIIVTDSV LSKERIPSNI KYLTASHLIA 

       310        320 
DAIIRIHERK PLSPLFSYRS DKKD

« Hide

References

[1]"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NEM316.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL766849 Genomic DNA. Translation: CAD46823.1.
RefSeqNP_735610.1. NC_004368.1.

3D structure databases

ProteinModelPortalQ8E568.
SMRQ8E568. Positions 10-317.
ModBaseSearch...

Protein-protein interaction databases

STRING211110.gbs1164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD46823; CAD46823; CAD46823.
GeneID1030168.
KEGGsan:gbs1164.
PATRIC19638204. VBIStrAga3577_1194.

Organism-specific databases

GenoListgbs1164.
CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMACMELSKR.
ProtClustDBPRK02458.

Enzyme and pathway databases

UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS2_STRA3
AccessionPrimary (citable) accession number: Q8E568
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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