Q8E4L6TYSY_STRA3Thymidylate synthaseTSTSase2.1.1.45thyAgbs1385Streptococcus agalactiae serotype III (strain NEM316)BacteriaBacillotaBacilliLactobacillalesStreptococcaceaeStreptococcusGenome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMPPyrimidine metabolism; dTTP biosynthesis.Homodimer.CytoplasmBelongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.CytoplasmMethyltransferaseNucleotide biosynthesisTransferasedUMPligand shared between dimeric partnersdUMPligand shared between dimeric partners(6R)-5,10-methylene-5,6,7,8-tetrahydrofolatedUMPligand shared between dimeric partnersdUMPligand shared between dimeric partners(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateMTKADLLFKDNITKIMSEGVFSEQARPRYKNGEMANSKYITGAFAEYDLSKGEFPITTLRPIPIKSAIKEIFWIYQDQTNDLVVLNDKYGVTYWNDWEVGHTGTIGQRYGAVVKKHNIISKLLKQLEDNPWNRRNVISLWDYEAFEETEGLLPCAFQTMFDVRRVNGELYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWRVGKFFYFINNLHIYDNQFEQAQELLKRQPSECNPKLVLNVPDGTDFFDIKPDDFALVDYDPIKPQLRFDLAI
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