Q8E4F2 (AROD_STRA3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	gbs1449

Organism

Streptococcus agalactiae serotype III [Complete proteome] [HAMAP]

Taxonomic identifier

216495 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000043192
Sites
	Active site	118	1	Proton acceptor By similarity
	Active site	143	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8E4F2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: C14DED66487061E5	FASTA	225	25,598
	10 20 30 40 50 60 MKIVVPVMPR SLEEAQEIDL SKFDSVDIIE WRADALPKDD IINVAPAIFE KFAGHEIIFT 70 80 90 100 110 120 LRTTREGGNI VLSDAEYVEL IQKINSIYNP DYIDFEYFSH KEVFQEMLEF PNLVLSYHNF 130 140 150 160 170 180 QETPENIMEI FSELTALAPR VVKIAVMPKN EQDVLDVMNY TRGFKTINPD QVYATVSMSK 190 200 210 220 IGRISRFAGD VTGSSWTFAY LDSSIAPGQI TISEMKRVKA LLDAD

References

[1]

"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease." Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F. Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NEM316 / Serotype III.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL766850 Genomic DNA. Translation: CAD47108.1.
RefSeq	NP_735886.1. NC_004368.1.
3D structure databases
HSSP	HSSP built from PDB template 1SFL based on UniProtKB Q8NXI0.
ProteinModelPortal	Q8E4F2.
SMR	Q8E4F2. Positions 1-223.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000002371; EBSTRP00000002289; EBSTRG00000002371.
GeneID	1030512.
GenomeReviews	Gene locus gbs1449 in contig AL732656_GR.
KEGG	san:gbs1449.
PATRIC	19638787. VBIStrAga3577_1480.
Organism-specific databases
GenoList	gbs1449.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027890.
HOGENOM	HBG732926.
OMA	SYHNFDE.
ProtClustDB	PRK02412.
Enzyme and pathway databases
BioCyc	SAGA211110:GBS1449-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STRA3

Accession

Primary (citable) accession number: Q8E4F2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program