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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Manganese 1UniRule annotation
Metal bindingi13 – 131Manganese 1UniRule annotation
Metal bindingi15 – 151Manganese 2UniRule annotation
Metal bindingi77 – 771Manganese 1UniRule annotation
Metal bindingi77 – 771Manganese 2UniRule annotation
Metal bindingi99 – 991Manganese 2UniRule annotation
Metal bindingi151 – 1511Manganese 2UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:gbs1467
OrganismiStreptococcus agalactiae serotype III (strain NEM316)
Taxonomic identifieri211110 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000823 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Probable manganese-dependent inorganic pyrophosphatasePRO_0000158587Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211110.gbs1467.

Structurei

3D structure databases

ProteinModelPortaliQ8E4D4.
SMRiQ8E4D4. Positions 2-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8E4D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKILVFGHQ NPDSDAIGSS VAFAYLAKEA WGLDTEAVAL GTPNEETAYV
60 70 80 90 100
LDYFGVQAPR VVESAKAEGV ETVILTDHNE FQQSISDIKD VTVYGVVDHH
110 120 130 140 150
RVANFETANP LYMRLEPVGS ASSIVYRMFK ENGVSVPKEL AGLLLSGLIS
160 170 180 190 200
DTLLLKSPTT HASDIPVAKE LAEIAGVNLE EYGLEMLKAG TNLSSKTAAE
210 220 230 240 250
LIDIDAKTFE LNGEAVRVAQ VNTVDINDIL ARQEEIEVAI QEAIVTEGYS
260 270 280 290 300
DFVLMITDIV NSNSEILALG SNMAKVEAAF EFTLENNHAF LAGAVSRKKQ
310
VVPQLTESYN A
Length:311
Mass (Da):33,597
Last modified:March 1, 2003 - v1
Checksum:i5EAE5E0A9245EAB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL766851 Genomic DNA. Translation: CAD47126.1.
RefSeqiWP_000036015.1. NC_004368.1.

Genome annotation databases

EnsemblBacteriaiCAD47126; CAD47126; CAD47126.
PATRICi19638823. VBIStrAga3577_1498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL766851 Genomic DNA. Translation: CAD47126.1.
RefSeqiWP_000036015.1. NC_004368.1.

3D structure databases

ProteinModelPortaliQ8E4D4.
SMRiQ8E4D4. Positions 2-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211110.gbs1467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD47126; CAD47126; CAD47126.
PATRICi19638823. VBIStrAga3577_1498.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_STRA3
AccessioniPrimary (citable) accession number: Q8E4D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.