Q8E2U1 (DEOC_STRA3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	gbs2024

Organism

Streptococcus agalactiae serotype III [Complete proteome] [HAMAP]

Taxonomic identifier

216495 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_0000057269
Sites
	Active site	153	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	182	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8E2U1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1629FF6D96E11EEC	FASTA	223	24,017
	10 20 30 40 50 60 MEVKDILKTV DHTLLATTAT WPEIQTILDD AMAYETASAC IPASYVKKAA EYVSGKLAIC 70 80 90 100 110 120 TVIGFPNGYS TTAAKVFECQ DAIKNGADEI DMVINLTDVK NGDFDTVEEE IRQIKAACQD 130 140 150 160 170 180 HILKVIVETC QLTKEELIEL CGVVTRSGAD FIKTSTGFST AGATFEDVEV MAKYVGEGVK 190 200 210 220 IKAAGGISSL EDAEKFIALG ASRLGTSRII KIVKNQKVEE GTY

References

[1]	"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease." Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F. Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NEM316 / Serotype III.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL766855 Genomic DNA. Translation: CAD47683.1.
RefSeq	NP_736457.1. NC_004368.1.
3D structure databases
ProteinModelPortal	Q8E2U1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000003364; EBSTRP00000003282; EBSTRG00000003364.
GeneID	1031407.
GenomeReviews	Gene locus gbs2024 in contig AL732656_GR.
KEGG	san:gbs2024.
PATRIC	19639981. VBIStrAga3577_2075.
Organism-specific databases
GenoList	gbs2024.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027905.
HOGENOM	HBG636421.
OMA	EEKIAMC.
ProtClustDB	PRK00507.
Enzyme and pathway databases
BioCyc	SAGA211110:GBS2024-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_STRA3

Accession

Primary (citable) accession number: Q8E2U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program