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Q8E2J5

- SYW_STRA3

UniProt

Q8E2J5 - SYW_STRA3

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei205 – 2051ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:gbs2127
OrganismiStreptococcus agalactiae serotype III (strain NEM316)
Taxonomic identifieri211110 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000823: Chromosome

Organism-specific databases

GenoListigbs2127.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Tryptophan--tRNA ligasePRO_0000136683Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi211110.gbs2127.

Structurei

3D structure databases

ProteinModelPortaliQ8E2J5.
SMRiQ8E2J5. Positions 2-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 209"HIGH" region
Motifi202 – 2065"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059941.
KOiK01867.
OMAiLELYWIL.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8E2J5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKPIILTGD RPTGKLHIGH YVGSLKNRVL LQNEGSYTLF VFLADQQALT
60 70 80 90 100
DHAKDPQTIV ESIGNVALDY LAVGLDPNKS TLFIQSQIPE LAELSMYYMN
110 120 130 140 150
LVSLARLERN PTVKTEIAQK GFGESIPAGF LVYPVAQAAD ITAFKANLVP
160 170 180 190 200
VGTDQKPMIE QTREIVRSFN HAYNCQVLVE PEGIYPENDA AGRLPGLDGN
210 220 230 240 250
AKMSKSLNNG IFLADDMDTV KKKVMSMYTD PNHIKVEEPG QIEGNMVFHY
260 270 280 290 300
LDVFGRDEDQ KEITAMKEHY QKGGLGDVKT KRYLLDILER ELSPIRERRL
310 320 330 340
EYAKDMGQVY QMLQKGSEKA QAVAASTLDE VKSAMGLNYF K
Length:341
Mass (Da):38,053
Last modified:March 1, 2003 - v1
Checksum:i5600BC8416DAEF8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL766856 Genomic DNA. Translation: CAD47786.1.
RefSeqiNP_736557.1. NC_004368.1.

Genome annotation databases

EnsemblBacteriaiCAD47786; CAD47786; CAD47786.
GeneIDi1030760.
KEGGisan:gbs2127.
PATRICi19640191. VBIStrAga3577_2180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL766856 Genomic DNA. Translation: CAD47786.1 .
RefSeqi NP_736557.1. NC_004368.1.

3D structure databases

ProteinModelPortali Q8E2J5.
SMRi Q8E2J5. Positions 2-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211110.gbs2127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD47786 ; CAD47786 ; CAD47786 .
GeneIDi 1030760.
KEGGi san:gbs2127.
PATRICi 19640191. VBIStrAga3577_2180.

Organism-specific databases

GenoListi gbs2127.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059941.
KOi K01867.
OMAi LELYWIL.
OrthoDBi EOG686NJQ.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
    Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
    Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NEM316.

Entry informationi

Entry nameiSYW_STRA3
AccessioniPrimary (citable) accession number: Q8E2J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3