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Q8E272

- ASSY_STRA5

UniProt

Q8E272 - ASSY_STRA5

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Protein
Argininosuccinate synthase
Gene
argG, SAG0125
Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Citrulline By similarity
Binding sitei115 – 1151ATP; via amide nitrogen By similarity
Binding sitei117 – 1171Aspartate By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei121 – 1211Citrulline By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei173 – 1731Citrulline By similarity
Binding sitei258 – 2581Citrulline By similarity
Binding sitei270 – 2701Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAGA208435:GHVY-179-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:SAG0125
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000821: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Argininosuccinate synthaseUniRule annotation
PRO_0000148644Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi208435.SAG0125.

Structurei

3D structure databases

ProteinModelPortaliQ8E272.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPECEYIR.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8E272-1 [UniParc]FASTAAdd to Basket

« Hide

MGKEKLILAY SGGLDTSVAI AWLKKDYDVI AVCMDVGEGK DLDFIHDKAL    50
TIGAIESYIL DVKDEFAEHF VLPALQAHAM YEQKYPLVSA LSRPIIAQKL 100
VEMAHQTGAT TIAHGCTGKG NDQVRFEVAI AALDPELKVI APVREWKWHR 150
EEEITFAKAN GVPIPADLDN PYSIDQNLWG RANECGVLEN PWNQAPEEAF 200
GITKSPEEAP DCAEYIDITF QNGKPIAINN QEMTLADLIL SLNEIAGKHG 250
IGRIDHVENR LVGIKSREIY ECPAAMVLLA AHKEIEDLTL VREVSHFKPI 300
LENELSNLIY NALWFSPATK AIIAYVKETQ KVVNGTTKVK LYKGSAQVVA 350
RHSSNSLYDE NLATYTAADS FDQDAAVGFI KLWGLPTQVN AQVNKG 396
Length:396
Mass (Da):43,698
Last modified:March 1, 2003 - v1
Checksum:i31CAC841B6E5AC52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009948 Genomic DNA. Translation: AAM99033.1.
RefSeqiNP_687161.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAM99033; AAM99033; SAG0125.
GeneIDi1012894.
KEGGisag:SAG0125.
PATRICi19626988. VBIStrAga72745_0123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009948 Genomic DNA. Translation: AAM99033.1 .
RefSeqi NP_687161.1. NC_004116.1.

3D structure databases

ProteinModelPortali Q8E272.
ModBasei Search...

Protein-protein interaction databases

STRINGi 208435.SAG0125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM99033 ; AAM99033 ; SAG0125 .
GeneIDi 1012894.
KEGGi sag:SAG0125.
PATRICi 19626988. VBIStrAga72745_0123.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi PECEYIR.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SAGA208435:GHVY-179-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-611 / 2603 V/R.

Entry informationi

Entry nameiASSY_STRA5
AccessioniPrimary (citable) accession number: Q8E272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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