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Q8E260 (UPPP_STRA5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:SAG0138
OrganismStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) [Complete proteome] [HAMAP]
Taxonomic identifier208435 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151208

Regions

Transmembrane45 – 6521Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8E260 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: AAB248BDE3670485

FASTA27931,504
        10         20         30         40         50         60 
MLIIELLKAL FLGVVEGVTE WLPVSSTGHL ILVQEFMKLN QSKSFVEMFN IVIQLGAIMA 

        70         80         90        100        110        120 
VIVIYFKRLN PFQPGKSARE IRLTWQLWLK VVIACIPSIL IALPFDNWFE AHFNFMIPIA 

       130        140        150        160        170        180 
IALIFYGFVF IWVEKRNAHL KPQVTELASM SYKTAFLIGC FQVLSIVPGT SRSGATILGA 

       190        200        210        220        230        240 
IIIGTSRSVA ADFTFFLAIP TMFGYSGLKA VKYFLDGNVL SLDQSLILLV ASLTAFVVSL 

       250        260        270 
YVIRFLTDYV KRHDFTIFGK YRIVLGSLLI LYWLVVHLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009948 Genomic DNA. Translation: AAM99046.1.
RefSeqNP_687174.1. NC_004116.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208435.SAG0138.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM99046; AAM99046; SAG0138.
GeneID1012907.
KEGGsag:SAG0138.
PATRIC19627014. VBIStrAga72745_0136.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycSAGA208435:GHVY-192-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_STRA5
AccessionPrimary (citable) accession number: Q8E260
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families