ID   WHIA_STRA5              Reviewed;         303 AA.
AC   Q8E130;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   OrderedLocusNames=SAG0533;
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R;
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D.,
RA   Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A.,
RA   Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T.,
RA   Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D.,
RA   Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
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DR   EMBL; AE009948; AAM99434.1; -; Genomic_DNA.
DR   RefSeq; NP_687562.1; NC_004116.1.
DR   RefSeq; WP_000011316.1; NC_004116.1.
DR   AlphaFoldDB; Q8E130; -.
DR   SMR; Q8E130; -.
DR   STRING; 208435.SAG0533; -.
DR   GeneID; 66885514; -.
DR   KEGG; sag:SAG0533; -.
DR   PATRIC; fig|208435.3.peg.529; -.
DR   HOGENOM; CLU_053282_0_0_9; -.
DR   OrthoDB; 401278at2; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   NCBIfam; TIGR00647; DNA_bind_WhiA; 1.
DR   PANTHER; PTHR37307; CELL DIVISION PROTEIN WHIA-RELATED; 1.
DR   PANTHER; PTHR37307:SF1; CELL DIVISION PROTEIN WHIA-RELATED; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; Homing endonucleases; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding; Reference proteome.
FT   CHAIN           1..303
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376572"
FT   DNA_BIND        272..303
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   303 AA;  34381 MW;  DB494200EBB4FD39 CRC64;
     MSFTVKVKEE LLGHKSENKM ELSAIIKMSG SLGLANHGLN LSITTENAKI ARHIYSMLEE
     HYHLQPEIKY HQKTNLRKNR VYTVFIEEKV DVILADLKLA DAFFGIETGI EHSILDNDEN
     GRAYLRGAFL STGTVREPDS GKYQLEIFSV YLDHAQDLAN LMKKFMLDAK VIEHKHGAVT
     YLQKAEDIMD FLIVIDAMEA RDAFEEIKMI RETRNDINRA NNVETANIAR TITASMKTIN
     NIIKIMDTIG FDALPSDLRQ VAQVRVAHPD YSIQQIADSL ETPLSKSGVN HRLRKINKIA
     DEL
//