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Q8E0M8 (UXUA_STRA5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannonate dehydratase

EC=4.2.1.8
Alternative name(s):
D-mannonate hydro-lyase
Gene names
Name:uxuA
Ordered Locus Names:SAG0702
OrganismStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) [Complete proteome] [HAMAP]
Taxonomic identifier208435 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dehydration of D-mannonate By similarity. HAMAP-Rule MF_00106

Catalytic activity

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP-Rule MF_00106

Cofactor

Fe2+ or Mn2+ ion By similarity. HAMAP-Rule MF_00106

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00106

Sequence similarities

Belongs to the mannonate dehydratase family.

Ontologies

Keywords
   LigandIron
Manganese
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglucuronate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmannonate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Mannonate dehydratase HAMAP-Rule MF_00106
PRO_0000170688

Sequences

Sequence LengthMass (Da)Tools
Q8E0M8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2D135E69BB3BC4DA

FASTA34839,249
        10         20         30         40         50         60 
MEMSFRWYGE DDPVTLENIG QIPTMKGIVT AIYDVPVGEV WSRERIQQLK EKVEAAGLKI 

        70         80         90        100        110        120 
SVIESVPVHE DIKLGRPTRD LLIDNYIQTV KNLAAEGIDT ICYNFMPVFD WTRTDLAYQY 

       130        140        150        160        170        180 
PDGSTALIFD ETVSKKMDPV NGELSLPGWD ASYSKEEMKA IMDAYAEIDE EKLWENLTYF 

       190        200        210        220        230        240 
IKRIIPEAEA VGVKMAIHPD DPPYSIFGLP RIITGLEAIE RFVKLYDSKS NGITLCVGSY 

       250        260        270        280        290        300 
ASDPQNDVLE ISRRAFELDR VNFVHARNIK LGDGKSFKES AHPSEYGSID MYEVIKLCHE 

       310        320        330        340 
FGFEGAIRPD HGRMIWGETG RPGYGLYDRA LGATYVSGLY EAVIKGSK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009948 Genomic DNA. Translation: AAM99589.1.
RefSeqNP_687717.1. NC_004116.1.

3D structure databases

ProteinModelPortalQ8E0M8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208435.SAG0702.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM99589; AAM99589; SAG0702.
GeneID1013506.
KEGGsag:SAG0702.
PATRIC19628234. VBIStrAga72745_0708.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1312.
HOGENOMHOG000195381.
KOK01686.
OMADFYESAH.
OrthoDBEOG6ZSP6Z.

Enzyme and pathway databases

BioCycSAGA208435:GHVY-793-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00106. UxuA.
InterProIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFPIRSF016049. Man_dehyd. 1 hit.
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR00695. uxuA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUXUA_STRA5
AccessionPrimary (citable) accession number: Q8E0M8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways