Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mannonate dehydratase

Gene

uxuA

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathway:ipentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciSAGA208435:GHVY-793-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:SAG0702
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000821 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Mannonate dehydratasePRO_0000170688Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8E0M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1312.
HOGENOMiHOG000195381.
KOiK01686.
OMAiAIVKAYH.
OrthoDBiEOG6ZSP6Z.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8E0M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMSFRWYGE DDPVTLENIG QIPTMKGIVT AIYDVPVGEV WSRERIQQLK
60 70 80 90 100
EKVEAAGLKI SVIESVPVHE DIKLGRPTRD LLIDNYIQTV KNLAAEGIDT
110 120 130 140 150
ICYNFMPVFD WTRTDLAYQY PDGSTALIFD ETVSKKMDPV NGELSLPGWD
160 170 180 190 200
ASYSKEEMKA IMDAYAEIDE EKLWENLTYF IKRIIPEAEA VGVKMAIHPD
210 220 230 240 250
DPPYSIFGLP RIITGLEAIE RFVKLYDSKS NGITLCVGSY ASDPQNDVLE
260 270 280 290 300
ISRRAFELDR VNFVHARNIK LGDGKSFKES AHPSEYGSID MYEVIKLCHE
310 320 330 340
FGFEGAIRPD HGRMIWGETG RPGYGLYDRA LGATYVSGLY EAVIKGSK
Length:348
Mass (Da):39,249
Last modified:March 1, 2003 - v1
Checksum:i2D135E69BB3BC4DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA. Translation: AAM99589.1.
RefSeqiNP_687717.1. NC_004116.1.
WP_000426045.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAM99589; AAM99589; SAG0702.
GeneIDi1013506.
KEGGisag:SAG0702.
PATRICi19628234. VBIStrAga72745_0708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA. Translation: AAM99589.1.
RefSeqiNP_687717.1. NC_004116.1.
WP_000426045.1. NC_004116.1.

3D structure databases

ProteinModelPortaliQ8E0M8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM99589; AAM99589; SAG0702.
GeneIDi1013506.
KEGGisag:SAG0702.
PATRICi19628234. VBIStrAga72745_0708.

Phylogenomic databases

eggNOGiCOG1312.
HOGENOMiHOG000195381.
KOiK01686.
OMAiAIVKAYH.
OrthoDBiEOG6ZSP6Z.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciSAGA208435:GHVY-793-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-611 / 2603 V/R.

Entry informationi

Entry nameiUXUA_STRA5
AccessioniPrimary (citable) accession number: Q8E0M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.