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Q8E0M8

- UXUA_STRA5

UniProt

Q8E0M8 - UXUA_STRA5

Protein

Mannonate dehydratase

Gene

uxuA

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of D-mannonate.UniRule annotation

    Catalytic activityi

    D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

    Cofactori

    Fe2+ or Mn2+ ion.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. mannonate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glucuronate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Iron, Manganese

    Enzyme and pathway databases

    BioCyciSAGA208435:GHVY-793-MONOMER.
    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
    Alternative name(s):
    D-mannonate hydro-lyaseUniRule annotation
    Gene namesi
    Name:uxuAUniRule annotation
    Ordered Locus Names:SAG0702
    OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
    Taxonomic identifieri208435 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000821: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Mannonate dehydratasePRO_0000170688Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208435.SAG0702.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8E0M8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannonate dehydratase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1312.
    HOGENOMiHOG000195381.
    KOiK01686.
    OMAiDFYESAH.
    OrthoDBiEOG6ZSP6Z.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00106. UxuA.
    InterProiIPR004628. Man_deHydtase.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view]
    PfamiPF03786. UxuA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016049. Man_dehyd. 1 hit.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR00695. uxuA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8E0M8-1 [UniParc]FASTAAdd to Basket

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    MEMSFRWYGE DDPVTLENIG QIPTMKGIVT AIYDVPVGEV WSRERIQQLK    50
    EKVEAAGLKI SVIESVPVHE DIKLGRPTRD LLIDNYIQTV KNLAAEGIDT 100
    ICYNFMPVFD WTRTDLAYQY PDGSTALIFD ETVSKKMDPV NGELSLPGWD 150
    ASYSKEEMKA IMDAYAEIDE EKLWENLTYF IKRIIPEAEA VGVKMAIHPD 200
    DPPYSIFGLP RIITGLEAIE RFVKLYDSKS NGITLCVGSY ASDPQNDVLE 250
    ISRRAFELDR VNFVHARNIK LGDGKSFKES AHPSEYGSID MYEVIKLCHE 300
    FGFEGAIRPD HGRMIWGETG RPGYGLYDRA LGATYVSGLY EAVIKGSK 348
    Length:348
    Mass (Da):39,249
    Last modified:March 1, 2003 - v1
    Checksum:i2D135E69BB3BC4DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009948 Genomic DNA. Translation: AAM99589.1.
    RefSeqiNP_687717.1. NC_004116.1.

    Genome annotation databases

    EnsemblBacteriaiAAM99589; AAM99589; SAG0702.
    GeneIDi1013506.
    KEGGisag:SAG0702.
    PATRICi19628234. VBIStrAga72745_0708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009948 Genomic DNA. Translation: AAM99589.1 .
    RefSeqi NP_687717.1. NC_004116.1.

    3D structure databases

    ProteinModelPortali Q8E0M8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208435.SAG0702.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM99589 ; AAM99589 ; SAG0702 .
    GeneIDi 1013506.
    KEGGi sag:SAG0702.
    PATRICi 19628234. VBIStrAga72745_0708.

    Phylogenomic databases

    eggNOGi COG1312.
    HOGENOMi HOG000195381.
    KOi K01686.
    OMAi DFYESAH.
    OrthoDBi EOG6ZSP6Z.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .
    BioCyci SAGA208435:GHVY-793-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00106. UxuA.
    InterProi IPR004628. Man_deHydtase.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view ]
    Pfami PF03786. UxuA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016049. Man_dehyd. 1 hit.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR00695. uxuA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-611 / 2603 V/R.

    Entry informationi

    Entry nameiUXUA_STRA5
    AccessioniPrimary (citable) accession number: Q8E0M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3