Q8E0M8 (UXUA_STRA5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	SAG0702

Organism

Streptococcus agalactiae serotype V [Complete proteome] [HAMAP]

Taxonomic identifier

216466 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Mannonate dehydratase HAMAP MF_00106		PRO_0000170688

Sequences

	Sequence		Length	Mass (Da)
	Q8E0M8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2D135E69BB3BC4DA	FASTA	348	39,249
	10 20 30 40 50 60 MEMSFRWYGE DDPVTLENIG QIPTMKGIVT AIYDVPVGEV WSRERIQQLK EKVEAAGLKI 70 80 90 100 110 120 SVIESVPVHE DIKLGRPTRD LLIDNYIQTV KNLAAEGIDT ICYNFMPVFD WTRTDLAYQY 130 140 150 160 170 180 PDGSTALIFD ETVSKKMDPV NGELSLPGWD ASYSKEEMKA IMDAYAEIDE EKLWENLTYF 190 200 210 220 230 240 IKRIIPEAEA VGVKMAIHPD DPPYSIFGLP RIITGLEAIE RFVKLYDSKS NGITLCVGSY 250 260 270 280 290 300 ASDPQNDVLE ISRRAFELDR VNFVHARNIK LGDGKSFKES AHPSEYGSID MYEVIKLCHE 310 320 330 340 FGFEGAIRPD HGRMIWGETG RPGYGLYDRA LGATYVSGLY EAVIKGSK

References

[1]

"Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae." Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N., Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D., Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F. , Madupu R., Lewis M.R., Radune D., Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A., Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002) [PubMed: 12200547] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-611 / 2603 V/R / Serotype V.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009948 Genomic DNA. Translation: AAM99589.1.
RefSeq	NP_687717.1. NC_004116.1.
3D structure databases
ProteinModelPortal	Q8E0M8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000006310; EBSTRP00000005977; EBSTRG00000006310.
GeneID	1013506.
GenomeReviews	Gene locus SAG0702 in contig AE009948_GR.
KEGG	sag:SAG0702.
PATRIC	19628234. VBIStrAga72745_0708.
TIGR	SAG0702.
Phylogenomic databases
GeneTree	EBGT00050000026584.
HOGENOM	HBG585927.
OMA	DIKLGKP.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	SAGA208435:SAG_0702-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_STRA5

Accession

Primary (citable) accession number: Q8E0M8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program