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Q8E093

- THIM_STRA5

UniProt

Q8E093 - THIM_STRA5

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381Substrate; via amide nitrogenUniRule annotation
    Binding sitei114 – 1141ATPUniRule annotation
    Binding sitei159 – 1591ATPUniRule annotation
    Binding sitei186 – 1861Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAGA208435:GHVY-932-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:SAG0841
    OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
    Taxonomic identifieri208435 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000821: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Hydroxyethylthiazole kinasePRO_0000156962Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208435.SAG0841.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8E093.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiNACTQLA.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8E093-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLEQLKEVN PLTICITNNV VKNFTANGLL ALGASPAMSE CIEDLEDLLK    50
    VADALLINIG TLTKESWQLY QEAIKIANKN QVPVVLDPVA AGASRFRLEV 100
    SLDLLKNYSI SLLTGNGSEI AALIGEKQAS KGADGGKVAD LESIAVKANQ 150
    VFDVPVVVTG ETDAIAVRGE VRLLQNGSPL MPLVTGTGCL LGAVLAAFIG 200
    SSDRSDDLAC LTEAMTVYNV AGEIAEKVAK GKGVGSFQVA FLDALSQMKS 250
    EMIMDK 256
    Length:256
    Mass (Da):26,959
    Last modified:March 1, 2003 - v1
    Checksum:i28C5E368FEFAB397
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009948 Genomic DNA. Translation: AAM99728.1.
    RefSeqiNP_687856.1. NC_004116.1.
    WP_000280422.1. NC_004116.1.

    Genome annotation databases

    EnsemblBacteriaiAAM99728; AAM99728; SAG0841.
    GeneIDi1013645.
    KEGGisag:SAG0841.
    PATRICi19628512. VBIStrAga72745_0847.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009948 Genomic DNA. Translation: AAM99728.1 .
    RefSeqi NP_687856.1. NC_004116.1.
    WP_000280422.1. NC_004116.1.

    3D structure databases

    ProteinModelPortali Q8E093.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208435.SAG0841.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM99728 ; AAM99728 ; SAG0841 .
    GeneIDi 1013645.
    KEGGi sag:SAG0841.
    PATRICi 19628512. VBIStrAga72745_0847.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi NACTQLA.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci SAGA208435:GHVY-932-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-611 / 2603 V/R.

    Entry informationi

    Entry nameiTHIM_STRA5
    AccessioniPrimary (citable) accession number: Q8E093
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3