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Q8DZX5

- TRMFO_STRA5

UniProt

Q8DZX5 - TRMFO_STRA5

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FAD.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156FADUniRule annotation

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciSAGA208435:GHVY-1060-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid
Ordered Locus Names:SAG0969
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000821: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000117270Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208435.SAG0969.

Structurei

3D structure databases

ProteinModelPortaliQ8DZX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiEIYFEGC.
OrthoDBiEOG6J74VT.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DZX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQSYINVIG AGLAGSEAAY QIAKRGIPVK LYEMRGVKST PQHKTDNFAE
60 70 80 90 100
LVCSNSFRGD SLTNAVGLLK EEMRRLDSII MRNGEAHRVP AGGAMAVDRE
110 120 130 140 150
GYSEAVTEEI HKHPLIEVIR DEITDIPGDA ITVIATGPLT SDSLAAKIHE
160 170 180 190 200
LNGGDGFYFY DAAAPIVDKN TIDINKVYLK SRYDKGEAAY LNCPMTKEEF
210 220 230 240 250
MAFHEALTTA EEAPLNSFEK EKYFEGCMPI EVMAKRGIKT MLYGPMKPVG
260 270 280 290 300
LEYPEDYKGP RDGEFKTPYA VVQLRQDNAA GSLYNIVGFQ THLKWGEQKR
310 320 330 340 350
VFQMIPGLEN AEFVRYGVMH RNSYMDSPNL LNQTFATRKN PNLFFAGQMT
360 370 380 390 400
GVEGYVESAA SGLVAGINAV RRFNGESEVV FPQTTAIGAL PHYITHTDSK
410 420 430 440
HFQPMNVNFG IIKELEGPRI RDKKERYEAI ATRALKDLEK FLNY
Length:444
Mass (Da):49,511
Last modified:March 1, 2003 - v1
Checksum:iCA438676C26001C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009948 Genomic DNA. Translation: AAM99853.1.
RefSeqiNP_687981.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAM99853; AAM99853; SAG0969.
GeneIDi1013773.
KEGGisag:SAG0969.
PATRICi19628768. VBIStrAga72745_0975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009948 Genomic DNA. Translation: AAM99853.1 .
RefSeqi NP_687981.1. NC_004116.1.

3D structure databases

ProteinModelPortali Q8DZX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208435.SAG0969.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM99853 ; AAM99853 ; SAG0969 .
GeneIDi 1013773.
KEGGi sag:SAG0969.
PATRICi 19628768. VBIStrAga72745_0975.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi EIYFEGC.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci SAGA208435:GHVY-1060-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-611 / 2603 V/R.

Entry informationi

Entry nameiTRMFO_STRA5
AccessioniPrimary (citable) accession number: Q8DZX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3