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Q8DZX5

- TRMFO_STRA5

UniProt

Q8DZX5 - TRMFO_STRA5

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciSAGA208435:GHVY-1060-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmFOUniRule annotation
    Synonyms:gid
    Ordered Locus Names:SAG0969
    OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
    Taxonomic identifieri208435 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000821: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000117270Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208435.SAG0969.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DZX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1206.
    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.
    OrthoDBiEOG6J74VT.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DZX5-1 [UniParc]FASTAAdd to Basket

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    MSQSYINVIG AGLAGSEAAY QIAKRGIPVK LYEMRGVKST PQHKTDNFAE    50
    LVCSNSFRGD SLTNAVGLLK EEMRRLDSII MRNGEAHRVP AGGAMAVDRE 100
    GYSEAVTEEI HKHPLIEVIR DEITDIPGDA ITVIATGPLT SDSLAAKIHE 150
    LNGGDGFYFY DAAAPIVDKN TIDINKVYLK SRYDKGEAAY LNCPMTKEEF 200
    MAFHEALTTA EEAPLNSFEK EKYFEGCMPI EVMAKRGIKT MLYGPMKPVG 250
    LEYPEDYKGP RDGEFKTPYA VVQLRQDNAA GSLYNIVGFQ THLKWGEQKR 300
    VFQMIPGLEN AEFVRYGVMH RNSYMDSPNL LNQTFATRKN PNLFFAGQMT 350
    GVEGYVESAA SGLVAGINAV RRFNGESEVV FPQTTAIGAL PHYITHTDSK 400
    HFQPMNVNFG IIKELEGPRI RDKKERYEAI ATRALKDLEK FLNY 444
    Length:444
    Mass (Da):49,511
    Last modified:March 1, 2003 - v1
    Checksum:iCA438676C26001C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009948 Genomic DNA. Translation: AAM99853.1.
    RefSeqiNP_687981.1. NC_004116.1.

    Genome annotation databases

    EnsemblBacteriaiAAM99853; AAM99853; SAG0969.
    GeneIDi1013773.
    KEGGisag:SAG0969.
    PATRICi19628768. VBIStrAga72745_0975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009948 Genomic DNA. Translation: AAM99853.1 .
    RefSeqi NP_687981.1. NC_004116.1.

    3D structure databases

    ProteinModelPortali Q8DZX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208435.SAG0969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM99853 ; AAM99853 ; SAG0969 .
    GeneIDi 1013773.
    KEGGi sag:SAG0969.
    PATRICi 19628768. VBIStrAga72745_0975.

    Phylogenomic databases

    eggNOGi COG1206.
    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.
    OrthoDBi EOG6J74VT.

    Enzyme and pathway databases

    BioCyci SAGA208435:GHVY-1060-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-611 / 2603 V/R.

    Entry informationi

    Entry nameiTRMFO_STRA5
    AccessioniPrimary (citable) accession number: Q8DZX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3