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Q8DZQ7

- CARB_STRA5

UniProt

Q8DZQ7 - CARB_STRA5

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Protein

Carbamoyl-phosphate synthase large chain

Gene

carB

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.UniRule annotation

Cofactori

Binds 4 magnesium or manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi284 – 2841Magnesium or manganese 1UniRule annotation
Metal bindingi298 – 2981Magnesium or manganese 1UniRule annotation
Metal bindingi298 – 2981Magnesium or manganese 2UniRule annotation
Metal bindingi300 – 3001Magnesium or manganese 2UniRule annotation
Metal bindingi820 – 8201Magnesium or manganese 3UniRule annotation
Metal bindingi832 – 8321Magnesium or manganese 3UniRule annotation
Metal bindingi832 – 8321Magnesium or manganese 4UniRule annotation
Metal bindingi834 – 8341Magnesium or manganese 4UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi159 – 21658ATPUniRule annotationAdd
BLAST
Nucleotide bindingi697 – 75458ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. arginine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAGA208435:GHVY-1133-MONOMER.
UniPathwayiUPA00068; UER00171.
UPA00070; UER00115.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamoyl-phosphate synthase large chainUniRule annotation (EC:6.3.5.5UniRule annotation)
Alternative name(s):
Carbamoyl-phosphate synthetase ammonia chainUniRule annotation
Gene namesi
Name:carBUniRule annotation
Ordered Locus Names:SAG1042
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000821: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10601060Carbamoyl-phosphate synthase large chainPRO_0000145048Add
BLAST

Interactioni

Subunit structurei

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.UniRule annotation

Protein-protein interaction databases

STRINGi208435.SAG1042.

Structurei

3D structure databases

ProteinModelPortaliQ8DZQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 327195ATP-grasp 1UniRule annotationAdd
BLAST
Domaini671 – 861191ATP-grasp 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 401401Carboxyphosphate synthetic domainAdd
BLAST
Regioni402 – 546145Oligomerization domainAdd
BLAST
Regioni547 – 929383Carbamoyl phosphate synthetic domainAdd
BLAST
Regioni930 – 1060131Allosteric domainAdd
BLAST

Sequence similaritiesi

Belongs to the CarB family.UniRule annotation
Contains 2 ATP-grasp domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0458.
HOGENOMiHOG000234582.
KOiK01955.
OMAiSASWTEM.
OrthoDBiEOG6J1DC6.

Family and domain databases

Gene3Di1.10.1030.10. 1 hit.
3.30.1490.20. 2 hits.
3.30.470.20. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
HAMAPiMF_01210_A. CPSase_L_chain_A.
MF_01210_B. CPSase_L_chain_B.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PRINTSiPR00098. CPSASE.
SMARTiSM01096. CPSase_L_D3. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF48108. SSF48108. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
TIGRFAMsiTIGR01369. CPSaseII_lrg. 1 hit.
PROSITEiPS50975. ATP_GRASP. 2 hits.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DZQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKRTDIRKI MVIGSGPIVI GQAAEFDYSG TQACLSLKEE GYQVVLVNSN
60 70 80 90 100
PATIMTDKDI ADKVYIEPIT LEFVTRILRK ERPDALLPTL GGQTGLNMAM
110 120 130 140 150
ALSKNGILEE LNVELLGTKL SAIDKAEDRD LFKQLMEELN QPIPESEIVN
160 170 180 190 200
SVEEAIQFAE QIGYPLIVRP AFTLGGTGGG MCDNQEQLVD ITTKGLKLSP
210 220 230 240 250
VTQCLIERSI AGFKEIEYEV MRDAADNALV VCNMENFDPV GIHTGDSIVF
260 270 280 290 300
APAQTLSDVE NQLLRDASLD IIRALKIEGG CNVQLALDPN SFKYYVIEVN
310 320 330 340 350
PRVSRSSALA SKATGYPIAK LAAKIAVGLT LDEVINPITK TTYAMFEPAL
360 370 380 390 400
DYVVAKMPRF PFDKFESGDR KLGTQMKATG EVMAIGRNIE ESLLKACRSL
410 420 430 440 450
EIGVDHIKIA DLDNVSDDVL LEKIRKAEDD RLFYLAEALR RHYSIEKLAS
460 470 480 490 500
LTSIDSFFLD KLRVIVELED LLSKNRLDIN ILKKVKNKGF SDKAIASLWQ
510 520 530 540 550
INEDQVRNMR KEAGILPVYK MVDTCASEFD SATPYFYSTY AVENESLISD
560 570 580 590 600
KASILVLGSG PIRIGQGVEF DYATVHSVKA IRESGFEAII MNSNPETVST
610 620 630 640 650
DFSISDKLYF EPLTFEDVMN VIDLEKPEGV ILQFGGQTAI NLAKDLNKAG
660 670 680 690 700
VKILGTQLED LDRAENRKQF EATLQALNIP QPPGFTATTE EEAVNAAQKI
710 720 730 740 750
GYPVLVRPSY VLGGRAMKIV ENEEDLRHYM TTAVKASPDH PVLIDAYLIG
760 770 780 790 800
KECEVDAISD GQNILIPGIM EHIERSGVHS GDSMAVYPPQ TLSETIIETI
810 820 830 840 850
VDYTKRLAIG LNCIGMMNIQ FVIKDQKVYV IEVNPRASRT LPFLSKVTHI
860 870 880 890 900
PMAQVATKVI LGDKLCNFTY GYDLYPASDM VHIKAPVFSF TKLAKVDSLL
910 920 930 940 950
GPEMKSTGEV MGSDINLQKA LYKAFEAAYL HMPDYGNIVF TVDDTDKEEA
960 970 980 990 1000
LELAKVYQSI GYRIYATQGT AIYFDANGLE TVLVGKLGEN DRNHIPDLIK
1010 1020 1030 1040 1050
NGKIQAVINT VGQNNIDNHD ALIIRRSAIE QGVPLFTSLD TAHAMFKVLE
1060
SRAFTLKVLD
Length:1,060
Mass (Da):117,093
Last modified:March 1, 2003 - v1
Checksum:i04C6D2B617E08274
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009948 Genomic DNA. Translation: AAM99924.1.
RefSeqiNP_688052.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAM99924; AAM99924; SAG1042.
GeneIDi1013846.
KEGGisag:SAG1042.
PATRICi19628924. VBIStrAga72745_1053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009948 Genomic DNA. Translation: AAM99924.1 .
RefSeqi NP_688052.1. NC_004116.1.

3D structure databases

ProteinModelPortali Q8DZQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208435.SAG1042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM99924 ; AAM99924 ; SAG1042 .
GeneIDi 1013846.
KEGGi sag:SAG1042.
PATRICi 19628924. VBIStrAga72745_1053.

Phylogenomic databases

eggNOGi COG0458.
HOGENOMi HOG000234582.
KOi K01955.
OMAi SASWTEM.
OrthoDBi EOG6J1DC6.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00171 .
UPA00070 ; UER00115 .
BioCyci SAGA208435:GHVY-1133-MONOMER.

Family and domain databases

Gene3Di 1.10.1030.10. 1 hit.
3.30.1490.20. 2 hits.
3.30.470.20. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
HAMAPi MF_01210_A. CPSase_L_chain_A.
MF_01210_B. CPSase_L_chain_B.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
Pfami PF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PRINTSi PR00098. CPSASE.
SMARTi SM01096. CPSase_L_D3. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48108. SSF48108. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
TIGRFAMsi TIGR01369. CPSaseII_lrg. 1 hit.
PROSITEi PS50975. ATP_GRASP. 2 hits.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-611 / 2603 V/R.

Entry informationi

Entry nameiCARB_STRA5
AccessioniPrimary (citable) accession number: Q8DZQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3