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Q8DZQ7

- CARB_STRA5

UniProt

Q8DZQ7 - CARB_STRA5

Protein

Carbamoyl-phosphate synthase large chain

Gene

carB

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.UniRule annotation

    Cofactori

    Binds 4 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi284 – 2841Magnesium or manganese 1UniRule annotation
    Metal bindingi298 – 2981Magnesium or manganese 1UniRule annotation
    Metal bindingi298 – 2981Magnesium or manganese 2UniRule annotation
    Metal bindingi300 – 3001Magnesium or manganese 2UniRule annotation
    Metal bindingi820 – 8201Magnesium or manganese 3UniRule annotation
    Metal bindingi832 – 8321Magnesium or manganese 3UniRule annotation
    Metal bindingi832 – 8321Magnesium or manganese 4UniRule annotation
    Metal bindingi834 – 8341Magnesium or manganese 4UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi159 – 21658ATPUniRule annotationAdd
    BLAST
    Nucleotide bindingi697 – 75458ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    2. arginine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis, Pyrimidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAGA208435:GHVY-1133-MONOMER.
    UniPathwayiUPA00068; UER00171.
    UPA00070; UER00115.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbamoyl-phosphate synthase large chainUniRule annotation (EC:6.3.5.5UniRule annotation)
    Alternative name(s):
    Carbamoyl-phosphate synthetase ammonia chainUniRule annotation
    Gene namesi
    Name:carBUniRule annotation
    Ordered Locus Names:SAG1042
    OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
    Taxonomic identifieri208435 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000821: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10601060Carbamoyl-phosphate synthase large chainPRO_0000145048Add
    BLAST

    Interactioni

    Subunit structurei

    Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.UniRule annotation

    Protein-protein interaction databases

    STRINGi208435.SAG1042.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DZQ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 327195ATP-grasp 1UniRule annotationAdd
    BLAST
    Domaini671 – 861191ATP-grasp 2UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 401401Carboxyphosphate synthetic domainAdd
    BLAST
    Regioni402 – 546145Oligomerization domainAdd
    BLAST
    Regioni547 – 929383Carbamoyl phosphate synthetic domainAdd
    BLAST
    Regioni930 – 1060131Allosteric domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CarB family.UniRule annotation
    Contains 2 ATP-grasp domains.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0458.
    HOGENOMiHOG000234582.
    KOiK01955.
    OMAiSASWTEM.
    OrthoDBiEOG6J1DC6.

    Family and domain databases

    Gene3Di1.10.1030.10. 1 hit.
    3.30.1490.20. 2 hits.
    3.30.470.20. 2 hits.
    3.40.50.1380. 1 hit.
    3.40.50.20. 2 hits.
    HAMAPiMF_01210_A. CPSase_L_chain_A.
    MF_01210_B. CPSase_L_chain_B.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006275. CarbamoylP_synth_lsu.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005480. CarbamoylP_synth_lsu_oligo.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR005483. CbamoylP_synth_lsu_CPSase_dom.
    IPR011607. MGS-like_dom.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PfamiPF00289. CPSase_L_chain. 2 hits.
    PF02786. CPSase_L_D2. 2 hits.
    PF02787. CPSase_L_D3. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PRINTSiPR00098. CPSASE.
    SMARTiSM01096. CPSase_L_D3. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48108. SSF48108. 1 hit.
    SSF52335. SSF52335. 1 hit.
    SSF52440. SSF52440. 2 hits.
    TIGRFAMsiTIGR01369. CPSaseII_lrg. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 2 hits.
    PS00866. CPSASE_1. 2 hits.
    PS00867. CPSASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DZQ7-1 [UniParc]FASTAAdd to Basket

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    MPKRTDIRKI MVIGSGPIVI GQAAEFDYSG TQACLSLKEE GYQVVLVNSN     50
    PATIMTDKDI ADKVYIEPIT LEFVTRILRK ERPDALLPTL GGQTGLNMAM 100
    ALSKNGILEE LNVELLGTKL SAIDKAEDRD LFKQLMEELN QPIPESEIVN 150
    SVEEAIQFAE QIGYPLIVRP AFTLGGTGGG MCDNQEQLVD ITTKGLKLSP 200
    VTQCLIERSI AGFKEIEYEV MRDAADNALV VCNMENFDPV GIHTGDSIVF 250
    APAQTLSDVE NQLLRDASLD IIRALKIEGG CNVQLALDPN SFKYYVIEVN 300
    PRVSRSSALA SKATGYPIAK LAAKIAVGLT LDEVINPITK TTYAMFEPAL 350
    DYVVAKMPRF PFDKFESGDR KLGTQMKATG EVMAIGRNIE ESLLKACRSL 400
    EIGVDHIKIA DLDNVSDDVL LEKIRKAEDD RLFYLAEALR RHYSIEKLAS 450
    LTSIDSFFLD KLRVIVELED LLSKNRLDIN ILKKVKNKGF SDKAIASLWQ 500
    INEDQVRNMR KEAGILPVYK MVDTCASEFD SATPYFYSTY AVENESLISD 550
    KASILVLGSG PIRIGQGVEF DYATVHSVKA IRESGFEAII MNSNPETVST 600
    DFSISDKLYF EPLTFEDVMN VIDLEKPEGV ILQFGGQTAI NLAKDLNKAG 650
    VKILGTQLED LDRAENRKQF EATLQALNIP QPPGFTATTE EEAVNAAQKI 700
    GYPVLVRPSY VLGGRAMKIV ENEEDLRHYM TTAVKASPDH PVLIDAYLIG 750
    KECEVDAISD GQNILIPGIM EHIERSGVHS GDSMAVYPPQ TLSETIIETI 800
    VDYTKRLAIG LNCIGMMNIQ FVIKDQKVYV IEVNPRASRT LPFLSKVTHI 850
    PMAQVATKVI LGDKLCNFTY GYDLYPASDM VHIKAPVFSF TKLAKVDSLL 900
    GPEMKSTGEV MGSDINLQKA LYKAFEAAYL HMPDYGNIVF TVDDTDKEEA 950
    LELAKVYQSI GYRIYATQGT AIYFDANGLE TVLVGKLGEN DRNHIPDLIK 1000
    NGKIQAVINT VGQNNIDNHD ALIIRRSAIE QGVPLFTSLD TAHAMFKVLE 1050
    SRAFTLKVLD 1060
    Length:1,060
    Mass (Da):117,093
    Last modified:March 1, 2003 - v1
    Checksum:i04C6D2B617E08274
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009948 Genomic DNA. Translation: AAM99924.1.
    RefSeqiNP_688052.1. NC_004116.1.

    Genome annotation databases

    EnsemblBacteriaiAAM99924; AAM99924; SAG1042.
    GeneIDi1013846.
    KEGGisag:SAG1042.
    PATRICi19628924. VBIStrAga72745_1053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009948 Genomic DNA. Translation: AAM99924.1 .
    RefSeqi NP_688052.1. NC_004116.1.

    3D structure databases

    ProteinModelPortali Q8DZQ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208435.SAG1042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM99924 ; AAM99924 ; SAG1042 .
    GeneIDi 1013846.
    KEGGi sag:SAG1042.
    PATRICi 19628924. VBIStrAga72745_1053.

    Phylogenomic databases

    eggNOGi COG0458.
    HOGENOMi HOG000234582.
    KOi K01955.
    OMAi SASWTEM.
    OrthoDBi EOG6J1DC6.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00171 .
    UPA00070 ; UER00115 .
    BioCyci SAGA208435:GHVY-1133-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1030.10. 1 hit.
    3.30.1490.20. 2 hits.
    3.30.470.20. 2 hits.
    3.40.50.1380. 1 hit.
    3.40.50.20. 2 hits.
    HAMAPi MF_01210_A. CPSase_L_chain_A.
    MF_01210_B. CPSase_L_chain_B.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006275. CarbamoylP_synth_lsu.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005480. CarbamoylP_synth_lsu_oligo.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR005483. CbamoylP_synth_lsu_CPSase_dom.
    IPR011607. MGS-like_dom.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    Pfami PF00289. CPSase_L_chain. 2 hits.
    PF02786. CPSase_L_D2. 2 hits.
    PF02787. CPSase_L_D3. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00098. CPSASE.
    SMARTi SM01096. CPSase_L_D3. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48108. SSF48108. 1 hit.
    SSF52335. SSF52335. 1 hit.
    SSF52440. SSF52440. 2 hits.
    TIGRFAMsi TIGR01369. CPSaseII_lrg. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 2 hits.
    PS00866. CPSASE_1. 2 hits.
    PS00867. CPSASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-611 / 2603 V/R.

    Entry informationi

    Entry nameiCARB_STRA5
    AccessioniPrimary (citable) accession number: Q8DZQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3