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Q8DZP5

- FTHS_STRA5

UniProt

Q8DZP5 - FTHS_STRA5

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, SAG1055
Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAGA208435:GHVY-1146-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:SAG1055
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000821: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199385Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208435.SAG1055.

Structurei

3D structure databases

ProteinModelPortaliQ8DZP5.
SMRiQ8DZP5. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DZP5-1 [UniParc]FASTAAdd to Basket

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MKTDIEIAQS VALKPIAEIV EQVGIGFDDI ELYGKYKAKL SFDKIEAVKS    50
QKVGKLILVT AINPTPAGEG KSTMSIGLAD ALNKIGKKTM IALREPSLGP 100
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALLDNHIHQ 150
GNELDIDQRR VIWKRVVDLN DRALRQVIVG LGSPVNGIPR EDGFDITVAS 200
EIMAILCLAT DLSDLKKRLS NIVVAYSRNR KPIYVKDLKI EGALTLILKD 250
TIKPNLVQTI YGTPALVHGG PFANIAHGCN SVLATSTALR LADYVVTEAG 300
FGADLGAEKF LDIKTPNLPT SPDAIVIVAT LRALKMHGGV SKEDLSQENV 350
EAVKRGFTNL ERHVNNMRQY GVPVVVAINQ FTADTESEIA TLKTLCSNID 400
VAVELASVWE DGADGGLELA QTVANVIETQ SSNYKRLYND EDTIEEKIKK 450
IVTKIYGGNK VHFGPKAQIQ LKEFSDNGWD KMPICMAKTQ YSFSDNPNLL 500
GAPTDFDITV REFVPKTGAG FIVALTGDVL TMPGLPKKPA ALNMDVLEDG 550
TAIGLF 556
Length:556
Mass (Da):59,945
Last modified:March 1, 2003 - v1
Checksum:iC656CA69077C5D35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009948 Genomic DNA. Translation: AAM99936.1.
RefSeqiNP_688064.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAM99936; AAM99936; SAG1055.
GeneIDi1013859.
KEGGisag:SAG1055.
PATRICi19628948. VBIStrAga72745_1065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009948 Genomic DNA. Translation: AAM99936.1 .
RefSeqi NP_688064.1. NC_004116.1.

3D structure databases

ProteinModelPortali Q8DZP5.
SMRi Q8DZP5. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208435.SAG1055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM99936 ; AAM99936 ; SAG1055 .
GeneIDi 1013859.
KEGGi sag:SAG1055.
PATRICi 19628948. VBIStrAga72745_1065.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SAGA208435:GHVY-1146-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-611 / 2603 V/R.

Entry informationi

Entry nameiFTHS_STRA5
AccessioniPrimary (citable) accession number: Q8DZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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