Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8DZK7

- NADK_STRA5

UniProt

Q8DZK7 - NADK_STRA5

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD kinase

Gene

nadK

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561Proton acceptorUniRule annotation
Binding sitei158 – 1581NADUniRule annotation
Binding sitei160 – 1601NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 572NADUniRule annotation
Nucleotide bindingi132 – 1332NADUniRule annotation
Nucleotide bindingi171 – 1766NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAGA208435:GHVY-1185-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:SAG1094
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000821: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278NAD kinasePRO_0000229693Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208435.SAG1094.

Structurei

3D structure databases

ProteinModelPortaliQ8DZK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiIQMSEIA.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DZK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQMNFTDRA TRVAIIANGK YQSKRVASKL FAAFKHDPDF YLSKKDPDIV
60 70 80 90 100
ISIGGDGMLL SAFHMYEKQL DKVRFVGVHT GHLGFYTDYR DFEVDTLINN
110 120 130 140 150
LKNDKGEQIS YPILKVTITL EDGRVIRARA LNESTIKRIE KTMVADVVIN
160 170 180 190 200
QVVFERFRGD GILVSTPTGS TAYNKSLGGA VLHPTIEALQ LTEISSLNNR
210 220 230 240 250
VYRTLGSSVI IPKKDAIEIV PKRVGVYTIS IDNKTVHYKN VTKIEYSIDE
260 270
KSINFVSTPS HTSFWERVND AFIGEPEH
Length:278
Mass (Da):31,307
Last modified:March 1, 2003 - v1
Checksum:i7F6D0B08A2F535F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA. Translation: AAM99975.1.
RefSeqiNP_688103.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAM99975; AAM99975; SAG1094.
GeneIDi1013898.
KEGGisag:SAG1094.
PATRICi19629022. VBIStrAga72745_1102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA. Translation: AAM99975.1 .
RefSeqi NP_688103.1. NC_004116.1.

3D structure databases

ProteinModelPortali Q8DZK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208435.SAG1094.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM99975 ; AAM99975 ; SAG1094 .
GeneIDi 1013898.
KEGGi sag:SAG1094.
PATRICi 19629022. VBIStrAga72745_1102.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000275803.
KOi K00858.
OMAi IQMSEIA.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SAGA208435:GHVY-1185-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-611 / 2603 V/R.

Entry informationi

Entry nameiNADK_STRA5
AccessioniPrimary (citable) accession number: Q8DZK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3