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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei208ATPUniRule annotation1
Binding sitei296ATP; via carbonyl oxygenUniRule annotation1
Binding sitei327ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi354 – 357ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAGA208435:G1FZP-1864-MONOMER
UniPathwayiUPA00109; UER00185

Protein family/group databases

MoonProtiQ8DXT0

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:SAG1766
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000821 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001460111 – 398Phosphoglycerate kinaseAdd BLAST398

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8DXT0
SMRiQ8DXT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG

Family and domain databases

Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DXT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLTVKDVD LKGKKVLVRV DFNVPLKDGV ITNDNRITAA LPTIKYIIEQ
60 70 80 90 100
GGRAILFSHL GRVKEEADKE GKSLAPVAAD LAAKLGQDVV FPGVTRGAKL
110 120 130 140 150
EEAINALEDG QVLLVENTRF EDVDGKKESK NDEELGKYWA SLGDGIFVND
160 170 180 190 200
AFGTAHRAHA SNVGISANVE KAVAGFLLEN EIAYIQEAVE TPERPFVAIL
210 220 230 240 250
GGSKVSDKIG VIENLLEKAD KVLIGGGMTY TFYKAQGIEI GNSLVEEDKL
260 270 280 290 300
DVAKDLLEKS NGKLILPVDS KEANAFAGYT EVRDTEGEAV SEGFLGLDIG
310 320 330 340 350
PKSIAKFDEA LTGAKTVVWN GPMGVFENPD FQAGTIGVMD AIVKQPGVKS
360 370 380 390
IIGGGDSAAA AINLGRADKF SWISTGGGAS MELLEGKVLP GLAALTEK
Length:398
Mass (Da):42,114
Last modified:March 1, 2003 - v1
Checksum:iF9FEB723AFE9649F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA Translation: AAN00629.1
RefSeqiNP_688756.1, NC_004116.1
WP_001096753.1, NC_004116.1

Genome annotation databases

EnsemblBacteriaiAAN00629; AAN00629; SAG1766
GeneIDi1014575
KEGGisag:SAG1766
PATRICifig|208435.3.peg.1772

Similar proteinsi

Entry informationi

Entry nameiPGK_STRA5
AccessioniPrimary (citable) accession number: Q8DXT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health