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Protein

Sensor protein DltS

Gene

dltS

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system DltS/DltR. Regulates the expression of the dlt operon. Probably phosphorylates DltR (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein DltS (EC:2.7.13.3)
Gene namesi
Name:dltS
Ordered Locus Names:SAG1791
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000821 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747311 – 395Sensor protein DltSAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei180Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8DXQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 387Histidine kinasePROSITE-ProRule annotationAdd BLAST211

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000112224.
OMAiYLANITY.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DXQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSDLRKKFV FLTMSILIVV VLFLFAVSNR YNQYWDEYDA YRIVKLVAKN
60 70 80 90 100
DYLGIPGDEP IALVTIDNQK MVKIQSNNTD LTNDVIEKSS LKLLEQGKKS
110 120 130 140 150
RKWKSFIYSI KEYKDKTYTI AIMDLASYEV PYARRFLILV FTIFGFCLLA
160 170 180 190 200
AVSLYLSRFI VGPVETEMTR EKQFVSDASH ELKTPIAAIR ANVQVLEQQI
210 220 230 240 250
PGNRYLDHVV SETKRMEFLI EDLLNLSRLD EKRSKVNFKK LNLSVLCQEV
260 270 280 290 300
LLTYESLAYE EEKCLNDTIE DDVWIVGEES QIKQILIILL DNAIRHSLSK
310 320 330 340 350
SAIQFSLKQA RRKAILTISN PSAIYSKEVM DNLFERFYQA KDDHADSLSF
360 370 380 390
GLGLSIAKAI VERHKGRIRA YQEKDQLRLE VQLPIDGFWT NTMIN
Length:395
Mass (Da):45,764
Last modified:March 1, 2003 - v1
Checksum:i6FEDFE55E5A2CC15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA. Translation: AAN00654.1.
RefSeqiNP_688781.1. NC_004116.1.
WP_000490535.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAN00654; AAN00654; SAG1791.
GeneIDi1014600.
KEGGisag:SAG1791.
PATRICi19630429. VBIStrAga72745_1799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA. Translation: AAN00654.1.
RefSeqiNP_688781.1. NC_004116.1.
WP_000490535.1. NC_004116.1.

3D structure databases

ProteinModelPortaliQ8DXQ8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN00654; AAN00654; SAG1791.
GeneIDi1014600.
KEGGisag:SAG1791.
PATRICi19630429. VBIStrAga72745_1799.

Phylogenomic databases

HOGENOMiHOG000112224.
OMAiYLANITY.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLTS_STRA5
AccessioniPrimary (citable) accession number: Q8DXQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.