ID   Q8DXB9_STRA5            Unreviewed;       816 AA.
AC   Q8DXB9;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 98.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=SAG1932 {ECO:0000313|EMBL:AAN00794.1};
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435 {ECO:0000313|EMBL:AAN00794.1, ECO:0000313|Proteomes:UP000000821};
RN   [1] {ECO:0000313|EMBL:AAN00794.1, ECO:0000313|Proteomes:UP000000821}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R {ECO:0000313|Proteomes:UP000000821};
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin S., Kolonay J.F., Umayam L.A., Madupu R., Lewis M.R.,
RA   Radune D., Fedorova N.B., Scanlan D., Khouri H., Mulligan S., Carty H.A.,
RA   Cline R.T., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C.,
RA   Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R.,
RA   Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
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DR   EMBL; AE009948; AAN00794.1; -; Genomic_DNA.
DR   RefSeq; NP_688921.1; NC_004116.1.
DR   RefSeq; WP_000176333.1; NC_004116.1.
DR   AlphaFoldDB; Q8DXB9; -.
DR   STRING; 208435.SAG1932; -.
DR   KEGG; sag:SAG1932; -.
DR   PATRIC; fig|208435.3.peg.1937; -.
DR   HOGENOM; CLU_346100_0_0_9; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000821};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          518..762
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   816 AA;  92783 MW;  574962208481389B CRC64;
     MTLTFGKPSI TIRRLGVITS TYMMLGFILL CGFLHPSTIY SEEIKSDINS FISIDDEKTT
     VPIFDSTLDK LTNSIEERQL ELDSDTSDSL IVDDQKDKDM VIVLGDSDSQ EKLSPPLKSE
     IATEENRKQA NLAELNATQP NNRTTYIIPE SSHSIAEQQR FLIESKGYSV ALLNSDEFRK
     TAREDRGFER DKLRSLDIIP KGDLSTSNVI GNTDIASQIS LGFKKNAIQE HHLTKTFSQK
     DGKLSSVIEG MLAIGKEKVE KEIKYSGNLW QKLKAKAHCL VCCVDNLNFE DIKSYFQYYC
     HLNHQLKLPK GAILSAKTEV YRGGDFGRKN KDNVFGYRIP SLLKTEKGTL LVGADERIEQ
     ACDWGNIGMV IRRSEDDGVT WGKRETIVNL RNNPRVPLVT SGDYSGSPIN MDMALVQDTS
     SKTKRIFSIY DMFPEGRGVI SIANTPEKEY TQIGGQSYLN LYNNGKKSKV FTIRDKGIVY
     NFKGKKTDYH VITETTKSDH SNLGDIYKGK QLLGNIYFTK HKTSPFRLAK SSYVWMSYSD
     DDGRTWSSPR DITASLRQKG MKFLGIGPGK GIVLKWGPHA GRIIIPAYST NWKSHLRGSQ
     SSRLIYSDDH GKTWHTGKAV NDNRILSNGE KIHSLTMDNK KEQNTESVPV QLKNGDIKLF
     MRNLTGNLEV ATSKDGGETW QNHVKRYKEV HDAYVQLSAI RFEHDKKEYI LLVNANGPGK
     KRQDGYARLA QVNRNGSFKW LYHHHIQDGS FAYNSVQQLN NDKFGVLYEH REKHQNSFTL
     NYKVFNWSFL SQNTEKQGTL WEKMAANWHV LFKFYL
//