SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8DWL1

- PUR5_STRMU

UniProt

Q8DWL1 - PUR5_STRMU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, SMU_34
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-51-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:SMU_34
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000148258Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.34.

Structurei

3D structure databases

ProteinModelPortaliQ8DWL1.
SMRiQ8DWL1. Positions 15-333.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiPRIYGND.
OrthoDBiEOG61CM1V.
PhylomeDBiQ8DWL1.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DWL1-1 [UniParc]FASTAAdd to Basket

« Hide

MTEKNAYAQS GVDIEAGYEV VARIKKHVAR TERLGVMGAL GGFGGMFDLS    50
QLDVKEPVLI SGTDGVGTKL MLAIKYDKHN TIGQDCVAMC VNDIIAAGAE 100
PLYFLDYIAT GKNEPAKLEQ VVAGVAEGCV QAGAGLIGGE TAEMPGMYGK 150
DDYDLAGFAV GVAEKSQIID GSKVKEGDVL LGLASSGIHS NGYSLVRRVF 200
ADYTGEEELP ELEGKKLKDV LLEPTRIYVK AALPLIKEEL VNGIAHITGG 250
GFIENVPRMF GDDLAAEIEE DKVPVLPIFK ALEKYGEIKH DEMFEIFNMG 300
IGLMLAVSPE KVDRVKEVLD EPVYELGRIV KKADASVVIK 340
Length:340
Mass (Da):36,512
Last modified:March 1, 2003 - v1
Checksum:i421A7033A6591B73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN57823.1.
RefSeqiNP_720517.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN57823; AAN57823; SMU_34.
GeneIDi1029622.
KEGGismu:SMU_34.
PATRICi19662351. VBIStrMut61772_0029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN57823.1 .
RefSeqi NP_720517.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q8DWL1.
SMRi Q8DWL1. Positions 15-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.34.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN57823 ; AAN57823 ; SMU_34 .
GeneIDi 1029622.
KEGGi smu:SMU_34.
PATRICi 19662351. VBIStrMut61772_0029.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi PRIYGND.
OrthoDBi EOG61CM1V.
PhylomeDBi Q8DWL1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SMUT210007:GC7Z-51-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiPUR5_STRMU
AccessioniPrimary (citable) accession number: Q8DWL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi