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Q8DWL1

- PUR5_STRMU

UniProt

Q8DWL1 - PUR5_STRMU

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-51-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:SMU_34
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148258Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.34.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DWL1.
    SMRiQ8DWL1. Positions 15-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    KOiK01933.
    OMAiPRIYGND.
    OrthoDBiEOG61CM1V.
    PhylomeDBiQ8DWL1.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DWL1-1 [UniParc]FASTAAdd to Basket

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    MTEKNAYAQS GVDIEAGYEV VARIKKHVAR TERLGVMGAL GGFGGMFDLS    50
    QLDVKEPVLI SGTDGVGTKL MLAIKYDKHN TIGQDCVAMC VNDIIAAGAE 100
    PLYFLDYIAT GKNEPAKLEQ VVAGVAEGCV QAGAGLIGGE TAEMPGMYGK 150
    DDYDLAGFAV GVAEKSQIID GSKVKEGDVL LGLASSGIHS NGYSLVRRVF 200
    ADYTGEEELP ELEGKKLKDV LLEPTRIYVK AALPLIKEEL VNGIAHITGG 250
    GFIENVPRMF GDDLAAEIEE DKVPVLPIFK ALEKYGEIKH DEMFEIFNMG 300
    IGLMLAVSPE KVDRVKEVLD EPVYELGRIV KKADASVVIK 340
    Length:340
    Mass (Da):36,512
    Last modified:March 1, 2003 - v1
    Checksum:i421A7033A6591B73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN57823.1.
    RefSeqiNP_720517.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN57823; AAN57823; SMU_34.
    GeneIDi1029622.
    KEGGismu:SMU_34.
    PATRICi19662351. VBIStrMut61772_0029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN57823.1 .
    RefSeqi NP_720517.1. NC_004350.2.

    3D structure databases

    ProteinModelPortali Q8DWL1.
    SMRi Q8DWL1. Positions 15-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.34.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN57823 ; AAN57823 ; SMU_34 .
    GeneIDi 1029622.
    KEGGi smu:SMU_34.
    PATRICi 19662351. VBIStrMut61772_0029.

    Phylogenomic databases

    eggNOGi COG0150.
    KOi K01933.
    OMAi PRIYGND.
    OrthoDBi EOG61CM1V.
    PhylomeDBi Q8DWL1.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci SMUT210007:GC7Z-51-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.

    Entry informationi

    Entry nameiPUR5_STRMU
    AccessioniPrimary (citable) accession number: Q8DWL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3