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Q8DWK8

- PUR9_STRMU

UniProt

Q8DWK8 - PUR9_STRMU

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, SMU_37
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-54-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:SMU_37
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_0000192133Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.37.

Structurei

3D structure databases

ProteinModelPortaliQ8DWK8.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DWK8-1 [UniParc]FASTAAdd to Basket

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MTKRALISVS DKSGIVDFAQ ELKNLGWEIV STGGTKVALD KAGIDTIAID    50
DVTGFPEMMD GRVKTLHPNI HGGLLARRDL DSHVNAMKEH EITPIDLVVV 100
NLYPFKETIL KPDATYADAV ENIDIGGPSM LRSAAKNHAS VTVVVDPADY 150
AEILDELSAN GETSFETRKR LAAKVFRHTA AYDALIAEYF TAQVGEEKPE 200
KLTLTYDLKQ PMRYGENPQQ NADFYQKALP TAYSIASAQQ LNGKELSFNN 250
IRDADAAIRV IRDFKDRPTV VALKHMNPCG IGQADDIETA WDYAYEADLV 300
SIFGGIVVLN REVDAATAEK MHAIFLEIII APSYTDEALA ILTTKKKNLR 350
ILQLPFDAQE ASEAEKEYTG VVGGLLVQNQ DVVKESPADW QVVTKRQPTK 400
TEETALEFAW KAIKYVKSNG IIVTNDHMTL GVGPGQTNRV ASVRIAIDQA 450
KDRLDGAVLA SDAFFPFADN VEEIAAAGIK AIIQPGGSVR DQESIDMADK 500
YGIAMVFTGV RHFRH 515
Length:515
Mass (Da):56,467
Last modified:June 20, 2003 - v2
Checksum:iD0B77899CC8AB43C
GO

Sequence cautioni

The sequence AAN57826.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN57826.1. Different initiation.
RefSeqiNP_720520.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN57826; AAN57826; SMU_37.
GeneIDi1029616.
KEGGismu:SMU_37.
PATRICi19662357. VBIStrMut61772_0032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN57826.1 . Different initiation.
RefSeqi NP_720520.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q8DWK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN57826 ; AAN57826 ; SMU_37 .
GeneIDi 1029616.
KEGGi smu:SMU_37.
PATRICi 19662357. VBIStrMut61772_0032.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SMUT210007:GC7Z-54-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiPUR9_STRMU
AccessioniPrimary (citable) accession number: Q8DWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: May 14, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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