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Q8DWC2

- DEF_STRMU

UniProt

Q8DWC2 - DEF_STRMU

Protein

Peptide deformylase

Gene

def

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi131 – 1311IronUniRule annotation
    Metal bindingi174 – 1741IronUniRule annotation
    Active sitei175 – 1751UniRule annotation
    Metal bindingi178 – 1781IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-151-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:SMU_143c
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Peptide deformylasePRO_0000082856Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.143c.

    Structurei

    Secondary structure

    1
    204
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 75
    Helixi25 – 273
    Helixi40 – 5718
    Helixi59 – 657
    Beta strandi71 – 744
    Helixi75 – 784
    Beta strandi82 – 909
    Beta strandi101 – 11818
    Beta strandi120 – 1256
    Beta strandi144 – 1463
    Beta strandi148 – 1536
    Beta strandi159 – 1646
    Helixi166 – 17914
    Helixi184 – 1874
    Beta strandi201 – 2033

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3L87X-ray2.00A1-204[»]
    ProteinModelPortaliQ8DWC2.
    SMRiQ8DWC2. Positions 2-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    KOiK01462.
    OMAiHIDKENP.
    OrthoDBiEOG6PZXGQ.
    PhylomeDBiQ8DWC2.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DWC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAIKTITKA SHLIDMNDII REGHPTLRAV AQDVTFPLNE DDIILGEKML    50
    QFLKNSQDPV TAEKMELRGG VGLAAPQLDI SKRIIAVLIP NPEDKDGNPP 100
    KEAYALKEVM YNPRIIAHSV QDAALADGEG CLSVDRVVEG YVIRHSRVTI 150
    EYYDKNSDKK KLKLKGYQSI VVQHEIDHTN GIMFFDRINE KNPFEIKEGL 200
    LLIE 204
    Length:204
    Mass (Da):22,919
    Last modified:March 1, 2003 - v1
    Checksum:iCC8FB580FDFCB8A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN57921.1.
    RefSeqiNP_720615.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN57921; AAN57921; SMU_143c.
    GeneIDi1029717.
    KEGGismu:SMU_143c.
    PATRICi19662541. VBIStrMut61772_0122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN57921.1 .
    RefSeqi NP_720615.1. NC_004350.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3L87 X-ray 2.00 A 1-204 [» ]
    ProteinModelPortali Q8DWC2.
    SMRi Q8DWC2. Positions 2-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.143c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN57921 ; AAN57921 ; SMU_143c .
    GeneIDi 1029717.
    KEGGi smu:SMU_143c.
    PATRICi 19662541. VBIStrMut61772_0122.

    Phylogenomic databases

    eggNOGi COG0242.
    KOi K01462.
    OMAi HIDKENP.
    OrthoDBi EOG6PZXGQ.
    PhylomeDBi Q8DWC2.

    Enzyme and pathway databases

    BioCyci SMUT210007:GC7Z-151-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.

    Entry informationi

    Entry nameiDEF_STRMU
    AccessioniPrimary (citable) accession number: Q8DWC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3