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Q8DWC2

- DEF_STRMU

UniProt

Q8DWC2 - DEF_STRMU

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Protein

Peptide deformylase

Gene

def

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe(2+) ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi131 – 1311IronUniRule annotation
Metal bindingi174 – 1741IronUniRule annotation
Active sitei175 – 1751UniRule annotation
Metal bindingi178 – 1781IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-151-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:SMU_143c
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Peptide deformylasePRO_0000082856Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.143c.

Structurei

Secondary structure

1
204
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 75Combined sources
Helixi25 – 273Combined sources
Helixi40 – 5718Combined sources
Helixi59 – 657Combined sources
Beta strandi71 – 744Combined sources
Helixi75 – 784Combined sources
Beta strandi82 – 909Combined sources
Beta strandi101 – 11818Combined sources
Beta strandi120 – 1256Combined sources
Beta strandi144 – 1463Combined sources
Beta strandi148 – 1536Combined sources
Beta strandi159 – 1646Combined sources
Helixi166 – 17914Combined sources
Helixi184 – 1874Combined sources
Beta strandi201 – 2033Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3L87X-ray2.00A1-204[»]
ProteinModelPortaliQ8DWC2.
SMRiQ8DWC2. Positions 2-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiHIDKENP.
OrthoDBiEOG6PZXGQ.
PhylomeDBiQ8DWC2.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DWC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAIKTITKA SHLIDMNDII REGHPTLRAV AQDVTFPLNE DDIILGEKML
60 70 80 90 100
QFLKNSQDPV TAEKMELRGG VGLAAPQLDI SKRIIAVLIP NPEDKDGNPP
110 120 130 140 150
KEAYALKEVM YNPRIIAHSV QDAALADGEG CLSVDRVVEG YVIRHSRVTI
160 170 180 190 200
EYYDKNSDKK KLKLKGYQSI VVQHEIDHTN GIMFFDRINE KNPFEIKEGL

LLIE
Length:204
Mass (Da):22,919
Last modified:March 1, 2003 - v1
Checksum:iCC8FB580FDFCB8A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN57921.1.
RefSeqiNP_720615.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN57921; AAN57921; SMU_143c.
GeneIDi1029717.
KEGGismu:SMU_143c.
PATRICi19662541. VBIStrMut61772_0122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN57921.1 .
RefSeqi NP_720615.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3L87 X-ray 2.00 A 1-204 [» ]
ProteinModelPortali Q8DWC2.
SMRi Q8DWC2. Positions 2-204.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.143c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN57921 ; AAN57921 ; SMU_143c .
GeneIDi 1029717.
KEGGi smu:SMU_143c.
PATRICi 19662541. VBIStrMut61772_0122.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi HIDKENP.
OrthoDBi EOG6PZXGQ.
PhylomeDBi Q8DWC2.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-151-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiDEF_STRMU
AccessioniPrimary (citable) accession number: Q8DWC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3