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Q8DWB2

- PNP_STRMU

UniProt

Q8DWB2 - PNP_STRMU

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi489 – 4891MagnesiumUniRule annotation
    Metal bindingi495 – 4951MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-161-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:SMU_155
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 730730Polyribonucleotide nucleotidyltransferasePRO_0000329868Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.155.

    Structurei

    Secondary structure

    1
    730
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi238 – 25720
    Helixi261 – 28323
    Helixi289 – 31123

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3H36X-ray1.80A231-320[»]
    ProteinModelPortaliQ8DWB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8DWB2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini556 – 61560KHUniRule annotationAdd
    BLAST
    Domaini625 – 69369S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    KOiK00962.
    OMAiRRIITHD.
    OrthoDBiEOG6WT8CC.
    PhylomeDBiQ8DWB2.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DWB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQVFETIF AGKKLAVEIG QVAKQANGAA LVRYGDSTVL SAAVMSKKMS    50
    TGDFFPLQIN YEEKRYAAGK FPGGFNKREG RPSTDATLTA RLIDRPIRPM 100
    FAEGFRNEVQ VINTVLSYDA DASAPMAAMF GSSLALSISD IPFNGPIAGV 150
    QVAYLDGQYV INPTAEEKKA SLLELTVAGT KEAINMVESG AKELSEDIML 200
    EALLKGHEAV RELIAFQEEI IAAVGKEKAE VELLQVDADL QAEIVGKYNA 250
    DLQKAVQIEE KKAREIATEA VKEHVTAEYE ERYAEHEEHD RIMRDVAEIL 300
    EQMEHAEVRR LITEDKVRPD GRRVDEIRPL DAEIDFLPKV HGSGLFTRGQ 350
    TQALSVLTLA PMGDTQIVDG LDEEYKKRFM HHYNFPQYSV GETGRYGAPG 400
    RREIGHGALG ERALAQVLPS LEAFPYAIRL VAEVLESNGS SSQASICAGT 450
    LALMAGGVPI KAPVAGIAMG LISDGTNYTV LTDIQGLEDH FGDMDFKVAG 500
    TREGITALQM DIKIEGITPQ ILEEALAQAK KARFEILDVI EKVIPAPRLE 550
    LAPTAPKIDT IKVDVDKIKI VIGKGGETID KIIEETGVKI DIDEDGNIAI 600
    YSSDQEAINR TKEIIASLVR EAKVGEIYEA EVVRIEKFGA FVHLFDKTDA 650
    LVHISEIAWT RTNKVEDVLA VGDKVTVKVV KVDDKGRIDA SMKALLPRPP 700
    RSEKSNKEDH QSVRHHGSPK DDKGKEKYDK 730
    Length:730
    Mass (Da):80,055
    Last modified:March 1, 2003 - v1
    Checksum:iDF9A8A2DBA25703F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN57931.1.
    RefSeqiNP_720625.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN57931; AAN57931; SMU_155.
    GeneIDi1029726.
    KEGGismu:SMU_155.
    PATRICi19662561. VBIStrMut61772_0132.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN57931.1 .
    RefSeqi NP_720625.1. NC_004350.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3H36 X-ray 1.80 A 231-320 [» ]
    ProteinModelPortali Q8DWB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN57931 ; AAN57931 ; SMU_155 .
    GeneIDi 1029726.
    KEGGi smu:SMU_155.
    PATRICi 19662561. VBIStrMut61772_0132.

    Phylogenomic databases

    eggNOGi COG1185.
    KOi K00962.
    OMAi RRIITHD.
    OrthoDBi EOG6WT8CC.
    PhylomeDBi Q8DWB2.

    Enzyme and pathway databases

    BioCyci SMUT210007:GC7Z-161-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8DWB2.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.

    Entry informationi

    Entry nameiPNP_STRMU
    AccessioniPrimary (citable) accession number: Q8DWB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3