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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei258ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:G1FZX-335-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:SMU_330
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196641 – 485Glutamate--tRNA ligaseAdd BLAST485

Proteomic databases

PRIDEiQ8DVX9

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi210007.SMU_330

Structurei

3D structure databases

ProteinModelPortaliQ8DVX9
SMRiQ8DVX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi255 – 259"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
KOiK09698
OMAiAYYAFDT
PhylomeDBiQ8DVX9

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DVX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKIRVRYA PSPTGLLHIG NARTALFNYL YARHHGGDFI IRIEDTDRKR
60 70 80 90 100
HVEDGERSQL ENLRWLGMDW DESPETHENY RQSERLALYK KYIDQLLAEG
110 120 130 140 150
KAYKSYVTEE ELAAERERQE AAGETPRYIN EFLGMSADEK AAYIAKRQAA
160 170 180 190 200
GIVPTVRLKV NEAGIYKWHD MVKGDIEFEG GNIGGDWVIQ KKDGYPTYNF
210 220 230 240 250
AVVVDDHDMQ ISHVIRGDDH IANTPKQLMV YEALGWEAPA FAHMTLIINS
260 270 280 290 300
ETGKKLSKRD TNTLQFIEDY RQKGYLPEAV FNFIALLGWN PGGENEIFSR
310 320 330 340 350
QELIELFDEN RLSKSPAAFD QKKLDWMNNE YIKNADFDTI FALAKPYLES
360 370 380 390 400
AGRLTDKAKK LVELYQPQMK SIDEIVPLTD LFFEEFPELS EEEKEFMAGE
410 420 430 440 450
TVPIVLQAFK AKLEAMSDED FKSENIFPQI KAVQKETGIK GKNLFMPIRI
460 470 480
AVSGEMHGPE LPDTIFLLGK EKSIQHLEDM LEKLK
Length:485
Mass (Da):55,720
Last modified:March 1, 2003 - v1
Checksum:iDFA1E99D0CD1363F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA Translation: AAN58089.1
RefSeqiNP_720783.1, NC_004350.2
WP_002262517.1, NC_004350.2

Genome annotation databases

EnsemblBacteriaiAAN58089; AAN58089; SMU_330
GeneIDi1027887
KEGGismu:SMU_330
PATRICifig|210007.7.peg.285

Similar proteinsi

Entry informationi

Entry nameiSYE_STRMU
AccessioniPrimary (citable) accession number: Q8DVX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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