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Q8DVX9

- SYE_STRMU

UniProt

Q8DVX9 - SYE_STRMU

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Protein

Glutamate--tRNA ligase

Gene
gltX, SMU_330
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei258 – 2581ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-335-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:SMU_330
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Glutamate--tRNA ligaseUniRule annotationPRO_0000119664Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi210007.SMU.330.

Structurei

3D structure databases

ProteinModelPortaliQ8DVX9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 2111"HIGH" regionUniRule annotationAdd
BLAST
Motifi255 – 2595"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
KOiK09698.
OMAiVTGQTHG.
OrthoDBiEOG6DRPF7.
PhylomeDBiQ8DVX9.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DVX9-1 [UniParc]FASTAAdd to Basket

« Hide

MTNKIRVRYA PSPTGLLHIG NARTALFNYL YARHHGGDFI IRIEDTDRKR    50
HVEDGERSQL ENLRWLGMDW DESPETHENY RQSERLALYK KYIDQLLAEG 100
KAYKSYVTEE ELAAERERQE AAGETPRYIN EFLGMSADEK AAYIAKRQAA 150
GIVPTVRLKV NEAGIYKWHD MVKGDIEFEG GNIGGDWVIQ KKDGYPTYNF 200
AVVVDDHDMQ ISHVIRGDDH IANTPKQLMV YEALGWEAPA FAHMTLIINS 250
ETGKKLSKRD TNTLQFIEDY RQKGYLPEAV FNFIALLGWN PGGENEIFSR 300
QELIELFDEN RLSKSPAAFD QKKLDWMNNE YIKNADFDTI FALAKPYLES 350
AGRLTDKAKK LVELYQPQMK SIDEIVPLTD LFFEEFPELS EEEKEFMAGE 400
TVPIVLQAFK AKLEAMSDED FKSENIFPQI KAVQKETGIK GKNLFMPIRI 450
AVSGEMHGPE LPDTIFLLGK EKSIQHLEDM LEKLK 485
Length:485
Mass (Da):55,720
Last modified:March 1, 2003 - v1
Checksum:iDFA1E99D0CD1363F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58089.1.
RefSeqiNP_720783.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58089; AAN58089; SMU_330.
GeneIDi1027887.
KEGGismu:SMU_330.
PATRICi19662899. VBIStrMut61772_0285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58089.1 .
RefSeqi NP_720783.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q8DVX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.330.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58089 ; AAN58089 ; SMU_330 .
GeneIDi 1027887.
KEGGi smu:SMU_330.
PATRICi 19662899. VBIStrMut61772_0285.

Phylogenomic databases

eggNOGi COG0008.
KOi K09698.
OMAi VTGQTHG.
OrthoDBi EOG6DRPF7.
PhylomeDBi Q8DVX9.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-335-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiSYE_STRMU
AccessioniPrimary (citable) accession number: Q8DVX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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