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Q8DVQ4

- TRMB_STRMU

UniProt

Q8DVQ4 - TRMB_STRMU

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, SMU_416
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441S-adenosyl-L-methionine By similarity
Binding sitei69 – 691S-adenosyl-L-methionine By similarity
Binding sitei96 – 961S-adenosyl-L-methionine By similarity
Active sitei118 – 1181 By similarity
Binding sitei118 – 1181S-adenosyl-L-methionine By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei154 – 1541Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-418-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:SMU_416
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171402Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.416.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DVQ4.
    SMRiQ8DVQ4. Positions 6-211.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni124 – 1296Interaction with RNA Reviewed prediction
    Regioni191 – 1944Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiINYLEAT.
    OrthoDBiEOG6K6VBC.
    PhylomeDBiQ8DVQ4.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DVQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVRRRKGAK EHLENNPRYV ILKPEEVKGH WQEVFGNDHP IHIEVGSGKG    50
    RFITGMAAKN PQINYIGIDI QVSVLSHALD KVLDSQLPNV KLMLADGSSL 100
    MHYFADGEID LLYLNFSDPW PKKRHEKRRL TYKSFLDTYK KILPEKGEIH 150
    FKTDNRELFE YSLASFSQYG MILEQVWLDL HASDYENNVM TEYEEKFSQK 200
    GQVIYRVEAR F 211
    Length:211
    Mass (Da):24,736
    Last modified:March 1, 2003 - v1
    Checksum:i845107A15B261735
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN58170.1.
    RefSeqiNP_720864.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN58170; AAN58170; SMU_416.
    GeneIDi1029334.
    KEGGismu:SMU_416.
    PATRICi19663065. VBIStrMut61772_0366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN58170.1 .
    RefSeqi NP_720864.1. NC_004350.2.

    3D structure databases

    ProteinModelPortali Q8DVQ4.
    SMRi Q8DVQ4. Positions 6-211.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.416.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN58170 ; AAN58170 ; SMU_416 .
    GeneIDi 1029334.
    KEGGi smu:SMU_416.
    PATRICi 19663065. VBIStrMut61772_0366.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi INYLEAT.
    OrthoDBi EOG6K6VBC.
    PhylomeDBi Q8DVQ4.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci SMUT210007:GC7Z-418-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.

    Entry informationi

    Entry nameiTRMB_STRMU
    AccessioniPrimary (citable) accession number: Q8DVQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: March 1, 2003
    Last modified: July 9, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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