Q8DVM9 (PROA_STRMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	SMU_450

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity HAMAP MF_00412.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_0000189787

Sequences

	Sequence		Length	Mass (Da)
	Q8DVM9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 40EB07C1D5D68A79	FASTA	416	45,219
	10 20 30 40 50 60 MAIIDNLGQN AKKASFLLAQ LGTEAKNTAL LKVAEALLAE LPYILEENAK DVALAQEHGI 70 80 90 100 110 120 SAIMVDRLRL DEKRLQDIAS GVRDVAALGD PIGQVVRGYT NMVGLKIIQK RVPLGVIAMI 130 140 150 160 170 180 FESRPNVSVD AFSLAFKTGN AIILRGGRDA ICSNTALVNV IRRTLASFGL DENAVQLVED 190 200 210 220 230 240 TSHEVAKELM AAVDYVDVLI PRGGARLIQT VKKEAKVPVI ETGVGNVHIY VDEFADLDMA 250 260 270 280 290 300 SKIVVNAKTQ RPSVCNAAEG LLVHEKVASD FLPKLEAAIN QIHPVEFRAD DRAQKILKNA 310 320 330 340 350 360 QPASQEDYAT EFLDYIISVK IVNSLGEAID WINTYTSHHS ESIITRDIQA AERFQDEVDA 370 380 390 400 410 AAVYVNASTR FTDGFVFGLG AEIGISTQKL HARGPMGLEA LTSTKFYING KGQIRE

References

[1]

"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014133 Genomic DNA. Translation: AAN58200.1.
RefSeq	NP_720894.1. NC_004350.2.
3D structure databases
ProteinModelPortal	Q8DVM9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000012492; EBSTRP00000011974; EBSTRG00000012492.
GeneID	1029582.
GenomeReviews	Gene locus SMU_450 in contig AE014133_GR.
KEGG	smu:SMU_450.
NMPDR	fig|210007.1.peg.407.
PATRIC	19663127. VBIStrMut61772_0396.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027638.
HOGENOM	HBG318080.
OMA	YGICGAM.
ProtClustDB	PRK00197.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_450-MONOMER.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KO	K00147.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_STRMU

Accession

Primary (citable) accession number: Q8DVM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program