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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:SMU_456
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei53 – 73HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei113 – 133HelicalUniRule annotationAdd BLAST21
Transmembranei145 – 165HelicalUniRule annotationAdd BLAST21
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Transmembranei202 – 222HelicalUniRule annotationAdd BLAST21
Transmembranei228 – 248HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei318 – 338HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001089031 – 339Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST339

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_456.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
KOiK01000.
OMAiLMSPLHH.
PhylomeDBiQ8DVM4.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DVM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTTIIAGI ISFILTILAM PFFIRFYQLK KINGQQMHED VKQHLAKAGT
60 70 80 90 100
PTMGGTVFLL VAALVTFICA FVLHITGGPA FGATLAILFI VLIYGTIGFL
110 120 130 140 150
DDFLKIFKKI NQGLTAWQKM ALQLIGGLVF YLVHVKPSGT DSLNLFGFPL
160 170 180 190 200
HLGVFYIIFI LFWVVGFSNA VNLTDGIDGL ASISVVISLL TYSVIAYVQN
210 220 230 240 250
QFDVLLIIIS MVGALLGFFV YNHKPAKVFM GDVGSLALGA MLAAISITLR
260 270 280 290 300
QEWTLLIIGI VYVLETASVM LQVSYFKWTK KRKGEGQRIF RMTPFHHHLE
310 320 330
LGGLRLRESG KKWSEWQVDF FLWSIGLLGS LLILAILYL
Length:339
Mass (Da):37,677
Last modified:March 1, 2003 - v1
Checksum:i5C06BDAEFB2911A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58205.1.
RefSeqiNP_720899.1. NC_004350.2.
WP_002262090.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58205; AAN58205; SMU_456.
GeneIDi1027963.
KEGGismu:SMU_456.
PATRICifig|210007.7.peg.400.

Similar proteinsi

Entry informationi

Entry nameiMRAY_STRMU
AccessioniPrimary (citable) accession number: Q8DVM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families