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Protein

Guanylate kinase

Gene

gmk

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:SMU_478
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001706171 – 210Guanylate kinaseAdd BLAST210

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_478.

Structurei

3D structure databases

ProteinModelPortaliQ8DVK6.
SMRiQ8DVK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 184Guanylate kinase-likeUniRule annotationAdd BLAST180

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
KOiK00942.
OMAiYGTLKSE.
PhylomeDBiQ8DVK6.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DVK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERGLLIVF SGPSGVGKGT VRQEIFSTPD HQFEYSVSMT TRPQRLGEID
60 70 80 90 100
GVDYFFRTRE EFEELIKQGQ MLEYAEYVGN YYGTPLTYVN ETLDKGIDVF
110 120 130 140 150
LEIEVQGALQ VKQKVPDGVF IFLTPPDLAE LKDRLVGRGT DSQEVIAQRI
160 170 180 190 200
ERAKEEIALM REYDYAVVND EVKLAAERVK HIIETEHFRV ERVIGRYHKM
210
INEELPLPLR
Length:210
Mass (Da):24,220
Last modified:March 1, 2003 - v1
Checksum:i74BFC28B4F4DEC0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58224.1.
RefSeqiNP_720918.1. NC_004350.2.
WP_002263045.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58224; AAN58224; SMU_478.
GeneIDi1029597.
KEGGismu:SMU_478.
PATRICifig|210007.7.peg.418.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKGUA_STRMU
AccessioniPrimary (citable) accession number: Q8DVK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families