Q8DVK6 (KGUA_STRMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	SMU_478

Organism

Streptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]

Taxonomic identifier

210007 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus mutans

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000170617
Regions
	Domain	5 – 184	180	Guanylate kinase-like
	Nucleotide binding	12 – 19	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DVK6 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 74BFC28B4F4DEC0D	FASTA	210	24,220
	10 20 30 40 50 60 MSERGLLIVF SGPSGVGKGT VRQEIFSTPD HQFEYSVSMT TRPQRLGEID GVDYFFRTRE 70 80 90 100 110 120 EFEELIKQGQ MLEYAEYVGN YYGTPLTYVN ETLDKGIDVF LEIEVQGALQ VKQKVPDGVF 130 140 150 160 170 180 IFLTPPDLAE LKDRLVGRGT DSQEVIAQRI ERAKEEIALM REYDYAVVND EVKLAAERVK 190 200 210 HIIETEHFRV ERVIGRYHKM INEELPLPLR

References

[1]

"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014133 Genomic DNA. Translation: AAN58224.1.
RefSeq	NP_720918.1. NC_004350.2.
3D structure databases
ProteinModelPortal	Q8DVK6.
ModBase	Search...
Protein-protein interaction databases
STRING	210007.SMU.478.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN58224; AAN58224; SMU_478.
GeneID	1029597.
KEGG	smu:SMU_478.
PATRIC	19663171. VBIStrMut61772_0418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
KO	K00942.
OMA	FVIINEL.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	SMUT210007:GC7Z-474-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_STRMU

Accession

Primary (citable) accession number: Q8DVK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program