Q8DVF5 (TRPC_STRMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	SMU_535

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154261

Sequences

	Sequence		Length	Mass (Da)
	Q8DVF5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F014D45CE3695728	FASTA	255	28,261
	10 20 30 40 50 60 MTKEFLPTIL KQKQEELASL IMEEVKPLRL TYRLFDFLKE HHDQLQIVAE VKKASPSMGD 70 80 90 100 110 120 INLDVDIVKQ AQMYEAAGAA MISVLTDQVF FKGNIDFLAE ISGSVSIPTL AKDFIIDEKQ 130 140 150 160 170 180 IVRSRNAGAT VILLIVAALP EKRLKELYDF AAGLGLEVLV ETHNLSELEI AHRIGAQIIG 190 200 210 220 230 240 VNNRNLVTFE VDINTSLELS THFRDDKVYI SESGIFTGQD SKLVAPYFNA ILVGTALMQA 250 DNVADKVKEL AIDKG

References

[1]

"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014133 Genomic DNA. Translation: AAN58278.1.
RefSeq	NP_720972.1. NC_004350.2.
3D structure databases
ProteinModelPortal	Q8DVF5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000012703; EBSTRP00000012185; EBSTRG00000012703.
GeneID	1027902.
GenomeReviews	Gene locus SMU_535 in contig AE014133_GR.
KEGG	smu:SMU_535.
NMPDR	fig|210007.1.peg.485.
PATRIC	19663279. VBIStrMut61772_0472.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000029214.
HOGENOM	HBG540956.
OMA	FETDINT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_535-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STRMU

Accession

Primary (citable) accession number: Q8DVF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program