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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei140 – 1401GTPUniRule annotation
Binding sitei144 – 1441GTPUniRule annotation
Binding sitei188 – 1881GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 265GTPUniRule annotation
Nucleotide bindingi109 – 1113GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:SMU_552Imported
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)Imported
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi210007.SMU_552.

Structurei

3D structure databases

ProteinModelPortaliQ8DVD9.
SMRiQ8DVD9. Positions 30-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 206193TubulinInterPro annotationAdd
BLAST
Domaini208 – 325118Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
KOiK03531.
OMAiAQVIWGI.
PhylomeDBiQ8DVD9.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DVD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSFDAASV QGAVIKVIGV GGGGGNAINR MIDEGVAGVE FIAANTDIQA
60 70 80 90 100
LSSSKAETVI QLGPKLTRGL GAGGQPEIGR KAAEESEEAL TEALTGADMV
110 120 130 140 150
FITAGMGGGS GTGAAPVIAR IAKGLGSLTV AVVTRPFGFE GSKRGNYAIE
160 170 180 190 200
GINELRDEVD TLLIISNNNL LEIVDKKTPL LEALSEADNV LRQGVQGITD
210 220 230 240 250
LITSPGLINL DFADVKTVMA SKGNALMGIG IGTGEERVVE AARKAIYSPL
260 270 280 290 300
LETTIDGAED VIVNVTGGLD MTLTEAEEAS EIVNQAAGHG VNIWLGTSID
310 320 330 340 350
DSMKDEIRVT VVATGVRPDK ADQVSGIRRQ ASSYTQPRAQ QQAPSSNSAQ
360 370 380 390 400
PNFERRQNFD FDLNESPEMP AAEPQQTQSS SEPQQSAFGD WNLRRENIAR
410 420 430
PTEGEIDSQL KMSSFSADSD DDDELETPPF FKNR
Length:434
Mass (Da):45,743
Last modified:March 1, 2003 - v1
Checksum:iC44A4A980F4AB12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58294.1.
RefSeqiNP_720988.1. NC_004350.2.
WP_002263818.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58294; AAN58294; SMU_552.
GeneIDi1028023.
KEGGismu:SMU_552.
PATRICi19663309. VBIStrMut61772_0487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58294.1.
RefSeqiNP_720988.1. NC_004350.2.
WP_002263818.1. NC_004350.2.

3D structure databases

ProteinModelPortaliQ8DVD9.
SMRiQ8DVD9. Positions 30-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_552.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58294; AAN58294; SMU_552.
GeneIDi1028023.
KEGGismu:SMU_552.
PATRICi19663309. VBIStrMut61772_0487.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
KOiK03531.
OMAiAQVIWGI.
PhylomeDBiQ8DVD9.

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-544-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8DVD9_STRMU
AccessioniPrimary (citable) accession number: Q8DVD9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.