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Protein
Submitted name:

Uncharacterized protein

Gene

SMU_776

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei220 – 2201S-adenosyl-L-homocysteine; via carbonyl oxygenCombined sources
Binding sitei272 – 2721S-adenosyl-L-homocysteine; via amide nitrogenCombined sources
Binding sitei292 – 2921S-adenosyl-L-homocysteineCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseSAAS annotation, Transferase

Keywords - Biological processi

rRNA processingSAAS annotation

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-746-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:SMU_776Imported
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)Imported
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_776.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B78X-ray2.00A1-385[»]
3LDFX-ray2.23A1-385[»]
ProteinModelPortaliQ8DUW5.
SMRiQ8DUW5. Positions 1-385.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8DUW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 341182Methyltrans_SAMInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni242 – 2465S-adenosyl-L-homocysteine bindingCombined sources

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmI family.SAAS annotation
Contains PUA domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105DR4. Bacteria.
COG1092. LUCA.
KOiK06969.
OMAiDQHEVRD.
OrthoDBiEOG6DG2T1.
PhylomeDBiQ8DUW5.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR015947. PUA-like_domain.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
SSF88697. SSF88697. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DUW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLMVGSFA EKKLKRGVQL LSSRDYPNLN LDNQVVQLYS DADIFLGTAY
60 70 80 90 100
LSKQNKGVGW LISPKKVSLN VTYFIKLFQW SKDKRKNFAH SKLTTAYRLF
110 120 130 140 150
NQDGDSFGGV TIDCYGDFVL FSWYNSFVYQ IRDEIVAAFR QVYPNFLGAY
160 170 180 190 200
EKIRFKGIDN VSAHLYGQEA PEQFLILENG ISYNVFLNDG LMTGIFLDQR
210 220 230 240 250
QVRNELINGS AAGKTVLNLF SYTAAFSVAA AMGGAMATTS VDLAKRSRAL
260 270 280 290 300
SLAHFEANHL DMANHQLVVM DVFDYFKYAR RHHLTYDIII IDPPSFARNK
310 320 330 340 350
KEVFSVSKDY HKLIRQGLEI LSENGLIIAS TNAANMTVSQ FKKQIEKGFG
360 370 380
KQKHTYLDLQ QLPSDFAVNV QDESSNYLKV FTIKV
Length:385
Mass (Da):43,682
Last modified:March 1, 2003 - v1
Checksum:iD025EF430B79A23B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58496.1.
RefSeqiNP_721190.1. NC_004350.2.
WP_002263895.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58496; AAN58496; SMU_776.
GeneIDi1028166.
KEGGismu:SMU_776.
PATRICi19663709. VBIStrMut61772_0687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58496.1.
RefSeqiNP_721190.1. NC_004350.2.
WP_002263895.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B78X-ray2.00A1-385[»]
3LDFX-ray2.23A1-385[»]
ProteinModelPortaliQ8DUW5.
SMRiQ8DUW5. Positions 1-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58496; AAN58496; SMU_776.
GeneIDi1028166.
KEGGismu:SMU_776.
PATRICi19663709. VBIStrMut61772_0687.

Phylogenomic databases

eggNOGiENOG4105DR4. Bacteria.
COG1092. LUCA.
KOiK06969.
OMAiDQHEVRD.
OrthoDBiEOG6DG2T1.
PhylomeDBiQ8DUW5.

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-746-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8DUW5.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR015947. PUA-like_domain.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
SSF88697. SSF88697. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159Imported.
  2. "A putative sam-dependent methyltransferase from Streptococcus mutans."
    Nan J., Wang K.T., Su X.D.
    Submitted (OCT-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  3. "Crystal structure of SMU.776 complexed with SAH."
    Wang K.-T., Nan J., Su X.-D.
    Submitted (JAN-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

Entry informationi

Entry nameiQ8DUW5_STRMU
AccessioniPrimary (citable) accession number: Q8DUW5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.