Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8DUG2

- GCH1_STRMU

UniProt

Q8DUG2 - GCH1_STRMU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811ZincUniRule annotation
Metal bindingi84 – 841ZincUniRule annotation
Metal bindingi153 – 1531ZincUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-921-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:SMU_968
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192GTP cyclohydrolase 1PRO_0000119448Add
BLAST

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi210007.SMU.968.

Structurei

3D structure databases

ProteinModelPortaliQ8DUG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0302.
KOiK01495.
OMAiKPEISAF.
OrthoDBiEOG6XHC8G.
PhylomeDBiQ8DUG2.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DUG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEKIMSDQK KIEEAVYQLL EALGEDPNRE GLLDTPKRVA KMYQEMFAGL
60 70 80 90 100
NEDPKDQFTA VFSEEHEDVV LVKDIPFYSM CEHHLVPFHG LAHVAYIPSD
110 120 130 140 150
GCVTGLSKLA RAVEVVSKRP QLQERLTVQI ANALEEALKP KGVLVMIEAE
160 170 180 190
HMCMTMRGIK KPGSKTVTRV VRGICQSDKE TRQEIIAMIH HN
Length:192
Mass (Da):21,683
Last modified:March 1, 2003 - v1
Checksum:i0A582279F604D368
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58671.1.
RefSeqiNP_721365.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58671; AAN58671; SMU_968.
GeneIDi1028313.
KEGGismu:SMU_968.
PATRICi19664059. VBIStrMut61772_0862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58671.1 .
RefSeqi NP_721365.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q8DUG2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58671 ; AAN58671 ; SMU_968 .
GeneIDi 1028313.
KEGGi smu:SMU_968.
PATRICi 19664059. VBIStrMut61772_0862.

Phylogenomic databases

eggNOGi COG0302.
KOi K01495.
OMAi KPEISAF.
OrthoDBi EOG6XHC8G.
PhylomeDBi Q8DUG2.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SMUT210007:GC7Z-921-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiGCH1_STRMU
AccessioniPrimary (citable) accession number: Q8DUG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3