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Protein

NAD kinase

Gene

nadK

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei55Proton acceptorUniRule annotation1
Binding sitei157NADUniRule annotation1
Binding sitei159NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi55 – 56NADUniRule annotation2
Nucleotide bindingi131 – 132NADUniRule annotation2
Nucleotide bindingi170 – 175NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:SMU_1045c
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296941 – 277NAD kinaseAdd BLAST277

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_1045c.

Structurei

3D structure databases

ProteinModelPortaliQ8DU98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiIQMSEIA.
PhylomeDBiQ8DU98.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DU98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQMNFTDKI KVAIIANGKY QSKRLTAKLF AILRNDDRFY LTKKNPDIVI
60 70 80 90 100
TIGGDGMLLS AFHMYEKCLD HVRFVGIHTG HLGFYTDYRD FEVDKLLENL
110 120 130 140 150
HSDKGEKASY PILKVTATLA DGRQLTSRAL NEATIRRIEK TMVADVVINK
160 170 180 190 200
VHFERFRGDG ISVSTPTGST AYNKSLGGAV LHPTIEALQL TEISSLNNRV
210 220 230 240 250
FRTLGSSIIV PKKDKIEIVP KRLGSYVLSI DNKTYTHRNV AKIEYEIDRK
260 270
KISFVSTPSH TSFWERVKDA FIGDFDS
Length:277
Mass (Da):31,323
Last modified:March 1, 2003 - v1
Checksum:i1DC19AE1A27112CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58744.1.
RefSeqiNP_721438.1. NC_004350.2.
WP_002262293.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58744; AAN58744; SMU_1045c.
GeneIDi1028373.
KEGGismu:SMU_1045c.
PATRICi19664205. VBIStrMut61772_0935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58744.1.
RefSeqiNP_721438.1. NC_004350.2.
WP_002262293.1. NC_004350.2.

3D structure databases

ProteinModelPortaliQ8DU98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_1045c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58744; AAN58744; SMU_1045c.
GeneIDi1028373.
KEGGismu:SMU_1045c.
PATRICi19664205. VBIStrMut61772_0935.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiIQMSEIA.
PhylomeDBiQ8DU98.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_STRMU
AccessioniPrimary (citable) accession number: Q8DU98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.