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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton donor/acceptorUniRule annotation1
Active sitei151Schiff-base intermediate with acetaldehydeUniRule annotation1
Active sitei180Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

BioCyciSMUT210007:G1FZX-1066-MONOMER
UniPathwayiUPA00002; UER00468

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:SMU_1123
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000572711 – 220Deoxyribose-phosphate aldolaseAdd BLAST220

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_1123

Structurei

3D structure databases

ProteinModelPortaliQ8DU34
SMRiQ8DU34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0274 LUCA
KOiK01619
OMAiMNACIPP
PhylomeDBiQ8DU34

Family and domain databases

CDDicd00959 DeoC, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00114 DeoC_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011343 DeoC
IPR002915 DeoC/FbaB/lacD_aldolase
IPR028581 DeoC_typeI
PANTHERiPTHR10889 PTHR10889, 1 hit
PTHR10889:SF1 PTHR10889:SF1, 1 hit
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF001357 DeoC, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
TIGRFAMsiTIGR00126 deoC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DU34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKINQYIDHT LLKPESRQDQ IDKLIREAKT YNFASVCINP TWVSYAAKAL
60 70 80 90 100
EGTDIKVCTV IGFPLGATTS AVKAFETKDA ISHGADEVDM VINIGQAKSG
110 120 130 140 150
HFAFVEEDIR AVVEASGDKL VKVIIETCLL TDKEKIKACQ AAVAAGADFV
160 170 180 190 200
KTSTGFSTAG ARLDDVRLMR QTVGPDVGVK AAGGTRSLED AQAFIEAGAT
210 220
RIGTSAGVTI MEGKQTNSGY
Length:220
Mass (Da):23,364
Last modified:March 1, 2003 - v1
Checksum:i1C66B2C4F84CE83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA Translation: AAN58816.1
RefSeqiNP_721510.1, NC_004350.2
WP_002262220.1, NC_004350.2

Genome annotation databases

EnsemblBacteriaiAAN58816; AAN58816; SMU_1123
GeneIDi1028437
KEGGismu:SMU_1123
PATRICifig|210007.7.peg.1006

Similar proteinsi

Entry informationi

Entry nameiDEOC_STRMU
AccessioniPrimary (citable) accession number: Q8DU34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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