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Q8DTY0

- GLMS_STRMU

UniProt

Q8DTY0 - GLMS_STRMU

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, SMU_1187
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei599 – 5991For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:SMU_1187
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135390Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi210007.SMU.1187.

Structurei

3D structure databases

ProteinModelPortaliQ8DTY0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2
Add
BLAST
Domaini284 – 423140SIS 1
Add
BLAST
Domaini456 – 594139SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiDHRFYLV.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ8DTY0.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8DTY0-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGVVGN RNATDILMQG LEKLEYRGYD SAGIYVINQP ENGRLIKSVG    50
RIADLRAKIG IDVAGSTGIG HTRWATHGQA TEENAHPHAS ATGRLVLVHN 100
GVIENYLQIK ENYLAGHNLK GETDTEIAVH LIGQFVTDGL SVLESFKKAL 150
HIIEGSYAFA LIDSQNPDII YVAKNKSPLL IGLGEGYNMV CSDAMAMIRE 200
TNQFMEIHDK ELVVLTKDTA QVSDYDGNPV ERQAYTAELD LSDIGKGTYP 250
YYMLKEIDEQ PTVMRKLIST YANENGKLTV DPAIVKSVQE ADRIYILAAG 300
TSYNAGFASK SMIETLTDTP VELGIASEWG YNMPLLSKKP MFILLSQSGE 350
TADSRQVLVK ANAMGVPSLT ITNVPGSTLS REATYTMLLH AGPEIAVAST 400
KAYTAQIAAL AFLSKAVGEA NGKKEALEFD LVHELSIVAQ SIEASLSERE 450
VIEKKVANLL ATSRNAFYIG RGNDYYVAME ASLKLKEISY IQCEGFAAGE 500
LKHGTISLIE EGTPVLALIS SSETVAAHTR GNIQEVAARG ANVLTVVEEG 550
LNKEEDDVVV NQVHPYLSSI SMVIPTQLIA YYASLQRGLD VDKPRNLAKA 600
VTVE 604
Length:604
Mass (Da):65,421
Last modified:January 23, 2007 - v3
Checksum:iCD810381733F6455
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58876.1.
RefSeqiNP_721570.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58876; AAN58876; SMU_1187.
GeneIDi1028487.
KEGGismu:SMU_1187.
PATRICi19664463. VBIStrMut61772_1064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58876.1 .
RefSeqi NP_721570.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q8DTY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1187.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58876 ; AAN58876 ; SMU_1187 .
GeneIDi 1028487.
KEGGi smu:SMU_1187.
PATRICi 19664463. VBIStrMut61772_1064.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi DHRFYLV.
OrthoDBi EOG6KT2Q1.
PhylomeDBi Q8DTY0.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-1126-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiGLMS_STRMU
AccessioniPrimary (citable) accession number: Q8DTY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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